Technology Process of (7aR)-3-(phenylsuIfonyl)-3,7a,8,9,10,12-hexahydro-7H-pyrrolo [2',1':3,4][1,4]oxazepino[6,7-e]indole
There total 6 articles about (7aR)-3-(phenylsuIfonyl)-3,7a,8,9,10,12-hexahydro-7H-pyrrolo [2',1':3,4][1,4]oxazepino[6,7-e]indole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C25H28N2O6S;
With
trifluoroacetic acid;
In
dichloromethane;
for 2h;
With
sodium tris(acetoxy)borohydride;
In
tetrahydrofuran;
at 20 ℃;
for 0.25h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 20 °C
2.1: ammonium formate / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C
3.1: potassium hydroxide / methanol; water / 40 °C
4.1: manganese(IV) oxide / dichloromethane / 2 h / 20 °C
5.1: diamide; triphenylphosphine / dichloromethane / 20 °C
6.1: trifluoroacetic acid / dichloromethane / 2 h
6.2: 0.25 h / 20 °C
With
manganese(IV) oxide; potassium hydroxide; sodium hydroxide; diamide; ammonium formate; tetra(n-butyl)ammonium hydrogensulfate; triphenylphosphine; trifluoroacetic acid;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: ammonium formate / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C
2.1: potassium hydroxide / methanol; water / 40 °C
3.1: manganese(IV) oxide / dichloromethane / 2 h / 20 °C
4.1: diamide; triphenylphosphine / dichloromethane / 20 °C
5.1: trifluoroacetic acid / dichloromethane / 2 h
5.2: 0.25 h / 20 °C
With
manganese(IV) oxide; potassium hydroxide; diamide; ammonium formate; triphenylphosphine; trifluoroacetic acid;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; dichloromethane; water;
