2-(8,11-oxapentacyclo[5.4.0.0^2,6.0^3,10.0^5,9]undecane-8-amino)propyl 4-nitrobenzoate

Base Information

• Chemical Name: 2-(8,11-oxapentacyclo[5.4.0.0^2,6.0^3,10.0^5,9]undecane-8-amino)propyl 4-nitrobenzoate
• CAS No.: 1394229-96-9
• Molecular Formula: C₂₁H₂₂N₂O₅
• Molecular Weight: 382.416

Synonyms:2-(8,11-oxapentacyclo[5.4.0.0^2,6.0^3,10.0^5,9]undecane-8-amino)propyl 4-nitrobenzoate

Chemical Property of 2-(8,11-oxapentacyclo[5.4.0.0^2,6.0^3,10.0^5,9]undecane-8-amino)propyl 4-nitrobenzoate

Chemical Property:

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Technology Process of 2-(8,11-oxapentacyclo[5.4.0.0^2,6.0^3,10.0^5,9]undecane-8-amino)propyl 4-nitrobenzoate

There total 3 articles about 2-(8,11-oxapentacyclo[5.4.0.0^2,6.0^3,10.0^5,9]undecane-8-amino)propyl 4-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.96%

8-(3-aminopropanol)-8,11-oxapentacyclo[5.4.0.02,6.03,10.05,9]undecane (1394230-01-3) + 4-nitro-benzoic acid (62-23-7) → 2-(8,11-oxapentacyclo[5.4.0.02,6.03,10.05,9]undecane-8-amino)propyl 4-nitrobenzoate (1394229-96-9)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃;

DOI:10.3390/molecules23020308

Reference yield:

C14H17NO2 → 2-(8,11-oxapentacyclo[5.4.0.02,6.03,10.05,9]undecane-8-amino)propyl 4-nitrobenzoate (1394229-96-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / tetrahydrofuran; methanol

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 72 h / 5 - 20 °C

With dmap; sodium tetrahydroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.2174/1573406411208030361

Reference yield:

Cookson's diketone (2958-72-7) → 2-(8,11-oxapentacyclo[5.4.0.02,6.03,10.05,9]undecane-8-amino)propyl 4-nitrobenzoate (1394229-96-9)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran

2: sodium tetrahydroborate / tetrahydrofuran; methanol

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 72 h / 5 - 20 °C

With dmap; sodium tetrahydroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.2174/1573406411208030361

upstream raw materials:

8-(3-aminopropanol)-8,11-oxapentacyclo[5.4.0.0^2,6.0^3,10.0^5,9]undecane

4-nitro-benzoic acid

Cookson's diketone

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