(RS)-3-hydroxy-N-methoxy-N-methyl-4,4,4-triphenylbutanamide

Base Information

Chemical Name:(RS)-3-hydroxy-N-methoxy-N-methyl-4,4,4-triphenylbutanamide
CAS No.:1356445-91-4
Molecular Formula:C₂₄H₂₅NO₃
Molecular Weight:375.467
Hs Code.:

Synonyms:(RS)-3-hydroxy-N-methoxy-N-methyl-4,4,4-triphenylbutanamide

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Chemical Property of (RS)-3-hydroxy-N-methoxy-N-methyl-4,4,4-triphenylbutanamide

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Technology Process of (RS)-3-hydroxy-N-methoxy-N-methyl-4,4,4-triphenylbutanamide

There total 1 articles about (RS)-3-hydroxy-N-methoxy-N-methyl-4,4,4-triphenylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 42365-04-8
triphenylacetaldehyde

: 78191-00-1
N-Methoxy-N-methylacetamide

: 1356445-91-4
(RS)-3-hydroxy-N-methoxy-N-methyl-4,4,4-triphenylbutanamide

Guidance literature:: N-Methoxy-N-methylacetamide; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

triphenylacetaldehyde; In tetrahydrofuran; hexane; at -78 ℃; for 0.666667h; Inert atmosphere;
DOI:10.1021/jo2023119

Reference yield: 85.0%

: 1356445-91-4
(RS)-3-hydroxy-N-methoxy-N-methyl-4,4,4-triphenylbutanamide

: 69739-34-0
t-butyldimethylsiyl triflate

: 1356445-92-5
(RS)-3-(tert-butyldimethylsilyloxy)-N-methoxy-N-methyl-4,4,4-triphenylbutanamide

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; for 1h; Inert atmosphere;
DOI:10.1021/jo2023119

Reference yield:

: 1356445-91-4
(RS)-3-hydroxy-N-methoxy-N-methyl-4,4,4-triphenylbutanamide

: (2SR,4SR,6SR)-1,1,1-triphenyloctan-2,4,6-triol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 1 h / Inert atmosphere

2.1: tetrahydrofuran; diethyl ether / 0.67 h / -78 °C / Inert atmosphere

3.1: triethylamine / diethyl ether / -30 °C / Inert atmosphere

4.1: diethyl ether / 1 h / -78 °C / Inert atmosphere

5.1: diethyl methoxy borane / tetrahydrofuran; methanol / 0.25 h / -60 °C / Inert atmosphere

5.2: 2 h / -60 °C / Inert atmosphere

6.1: hydrogen fluoride / water; acetonitrile / 48 h / 0 - 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; diethyl methoxy borane; hydrogen fluoride; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetonitrile; 4.1: Aldol condensation;
DOI:10.1021/jo2023119