3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid {2-[3-chloro-5-(4-fluorophenyl)thiophen-2-yl]-1-methylethyl}amide

Base Information

• Chemical Name: 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid {2-[3-chloro-5-(4-fluorophenyl)thiophen-2-yl]-1-methylethyl}amide
• CAS No.: 1093356-12-7
• Molecular Formula: C₁₉H₁₇ClF₃N₃OS
• Molecular Weight: 427.878
• Mol file: 1093356-12-7.mol

Synonyms:3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid {2-[3-chloro-5-(4-fluorophenyl)thiophen-2-yl]-1-methylethyl}amide

Chemical Property of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid {2-[3-chloro-5-(4-fluorophenyl)thiophen-2-yl]-1-methylethyl}amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid {2-[3-chloro-5-(4-fluorophenyl)thiophen-2-yl]-1-methylethyl}amide

There total 5 articles about 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid {2-[3-chloro-5-(4-fluorophenyl)thiophen-2-yl]-1-methylethyl}amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid [2-(5-bromo-3-chlorothiophen-2-yl)-1-methylethyl]amide (1093356-17-2) + 4-fluoroboronic acid (1765-93-1) → 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid {2-[3-chloro-5-(4-fluorophenyl)thiophen-2-yl]-1-methylethyl}amide (1093356-12-7)

Guidance literature:

With sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; water; at 60 ℃; for 48h; Heating / reflux;

Reference yield:

3-chlorothiophene-2-carboxaldehyde (67482-48-8) → 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid {2-[3-chloro-5-(4-fluorophenyl)thiophen-2-yl]-1-methylethyl}amide (1093356-12-7)

Guidance literature:

Multi-step reaction with 5 steps

1: ammonium acetate / acetic acid / 5 h / 90 °C

2: lithium aluminium tetrahydride / diethyl ether / 4 h / 20 °C

3: bromine / acetic acid / 15 - 20 °C

4: dichloromethane / 16 h / 20 °C

5: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 48 h / 60 °C / Heating / reflux

With lithium aluminium tetrahydride; ammonium acetate; bromine; sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; acetic acid;

Reference yield:

3-chloro-2-((E)-nitropropenyl)thiophene (67482-53-5) → 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid {2-[3-chloro-5-(4-fluorophenyl)thiophen-2-yl]-1-methylethyl}amide (1093356-12-7)

Guidance literature:

Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / diethyl ether / 4 h / 20 °C

2: bromine / acetic acid / 15 - 20 °C

3: dichloromethane / 16 h / 20 °C

4: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 48 h / 60 °C / Heating / reflux

With lithium aluminium tetrahydride; bromine; sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; acetic acid;

upstream raw materials:

3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid [2-(5-bromo-3-chlorothiophen-2-yl)-1-methylethyl]amide

4-fluoroboronic acid

3-chlorothiophene-2-carboxaldehyde

3-chloro-2-((E)-nitropropenyl)thiophene