7-fluoro-1-[(1S,2S)-1-(3-fluorophenyl)-2,3-dihydroxypropyl]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one

Base Information

Chemical Name:7-fluoro-1-[(1S,2S)-1-(3-fluorophenyl)-2,3-dihydroxypropyl]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one
CAS No.:866209-70-3
Molecular Formula:C₁₉H₁₉F₂NO₃
Molecular Weight:347.362
Hs Code.:

Synonyms:7-fluoro-1-[(1S,2S)-1-(3-fluorophenyl)-2,3-dihydroxypropyl]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one

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Chemical Property of 7-fluoro-1-[(1S,2S)-1-(3-fluorophenyl)-2,3-dihydroxypropyl]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one

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Technology Process of 7-fluoro-1-[(1S,2S)-1-(3-fluorophenyl)-2,3-dihydroxypropyl]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one

There total 4 articles about 7-fluoro-1-[(1S,2S)-1-(3-fluorophenyl)-2,3-dihydroxypropyl]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.7%

: 866208-24-4
7-fluoro-3,3-dimethyl-1,3-dihydro-2H-indol-2-one

: [3-(3-fluoro-phenyl)-oxiranyl]-methanol

: 866209-70-3
7-fluoro-1-[(1S,2S)-1-(3-fluorophenyl)-2,3-dihydroxypropyl]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one

Guidance literature:: 7-fluoro-3,3-dimethyl-1,3-dihydro-2H-indol-2-one; [3-(3-fluoro-phenyl)-oxiranyl]-methanol; With titanium(IV) isopropylate; lithium hexamethyldisilazane; In N,N-dimethyl-formamide; toluene; at 40 - 45 ℃; for 3 - 4h;

With hydrogenchloride; In water; N,N-dimethyl-formamide; toluene; at 20 - 25 ℃; Product distribution / selectivity;

Reference yield: 72.0%

: 693220-50-7
(2R,3R)-3-(3-fluorophenyl)-2-(hydroxymethyl)oxirane

: C₁₀H₉FNO^(1-)*Li⁽¹⁺⁾

: 866209-70-3
7-fluoro-1-[(1S,2S)-1-(3-fluorophenyl)-2,3-dihydroxypropyl]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one

Guidance literature:: (2R,3R)-3-(3-fluorophenyl)-2-(hydroxymethyl)oxirane; With titanium(IV) isopropylate; In decane; toluene; at 3 - 20 ℃; Large scale reaction;

C₁₀H₉FNO^(1-)*Li⁽¹⁺⁾; In decane; N,N-dimethyl-formamide; toluene; at 20 - 45 ℃; Large scale reaction;
DOI:10.1021/op900141r

Reference yield:

: 866208-24-4
7-fluoro-3,3-dimethyl-1,3-dihydro-2H-indol-2-one

: 693220-50-7
(2R,3R)-3-(3-fluorophenyl)-2-(hydroxymethyl)oxirane

: 866209-70-3
7-fluoro-1-[(1S,2S)-1-(3-fluorophenyl)-2,3-dihydroxypropyl]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one

Guidance literature:: (2R,3R)-3-(3-fluorophenyl)-2-(hydroxymethyl)oxirane; With titanium(IV) isopropylate; In tetrahydrofuran; at 7 - 20 ℃; for 0.666667h;

7-fluoro-3,3-dimethyl-1,3-dihydro-2H-indol-2-one; With lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 40h;

With hydrogenchloride; In tetrahydrofuran; water; N,N-dimethyl-formamide; at 15 ℃; Product distribution / selectivity;