7-(3-Benzyloxy-benzyl)-2-methylsulfanyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one

Base Information

Chemical Name:7-(3-Benzyloxy-benzyl)-2-methylsulfanyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one
CAS No.:156601-69-3
Molecular Formula:C₂₁H₁₉N₃O₂S
Molecular Weight:377.467
Hs Code.:

Synonyms:7-(3-Benzyloxy-benzyl)-2-methylsulfanyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one

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Chemical Property of 7-(3-Benzyloxy-benzyl)-2-methylsulfanyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one

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Technology Process of 7-(3-Benzyloxy-benzyl)-2-methylsulfanyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one

There total 9 articles about 7-(3-Benzyloxy-benzyl)-2-methylsulfanyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 146386-19-8
3-(3-Benzoyl-2-methyl-isothioureido)-4-(3-benzyloxy-benzyl)-1H-pyrrole-2-carboxylic acid methyl ester

: 132138-66-0
2-Amino-3,5-dihydro-7-(3-benzyloxyphenylmethyl)-4H-pyrrolo[3,2-d]pyrimidin-4-one

: 156601-69-3
7-(3-Benzyloxy-benzyl)-2-methylsulfanyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one

Guidance literature:: With ammonia; In methanol; at 100 ℃; for 22h;
DOI:10.1021/jm00053a008

Reference yield:

: 1700-37-4
3-Benzyloxybenzaldehyde

: 156601-69-3
7-(3-Benzyloxy-benzyl)-2-methylsulfanyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 9 steps

1: ammonium acetate, pyridine / toluene / 44 h / Heating

2: Mg, MeOH

3: NaH / tetrahydrofuran / 24 h / Ambient temperature

4: AcONa / methanol; H₂O / Ambient temperature

5: 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / CH₂Cl₂ / 24 h / Ambient temperature

6: Na₂CO₃ / methanol / 24 h / Ambient temperature

7: 91.6 percent / CH₂Cl₂ / 1 h / Ambient temperature

8: 97 percent / 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / CH₂Cl₂ / 1 h / 0 - 20 °C

9: NH₃ / methanol / 22 h / 100 °C

With pyridine; ammonium acetate; methanol; DBN; ammonia; sodium acetate; sodium hydride; sodium carbonate; magnesium; In tetrahydrofuran; methanol; dichloromethane; water; toluene;
DOI:10.1021/jm00053a008

Reference yield:

: 57591-62-5
(E)-3-(3-Benzyloxy-phenyl)-acrylonitrile

: 156601-69-3
7-(3-Benzyloxy-benzyl)-2-methylsulfanyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 8 steps

1: Mg, MeOH

2: NaH / tetrahydrofuran / 24 h / Ambient temperature

3: AcONa / methanol; H₂O / Ambient temperature

4: 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / CH₂Cl₂ / 24 h / Ambient temperature

5: Na₂CO₃ / methanol / 24 h / Ambient temperature

6: 91.6 percent / CH₂Cl₂ / 1 h / Ambient temperature

7: 97 percent / 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / CH₂Cl₂ / 1 h / 0 - 20 °C

8: NH₃ / methanol / 22 h / 100 °C

With methanol; DBN; ammonia; sodium acetate; sodium hydride; sodium carbonate; magnesium; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm00053a008