ethyl 1-(2-hydroxypropan-2-yl)-3-methylenecyclohexanecarboxylate

Base Information

• Chemical Name: ethyl 1-(2-hydroxypropan-2-yl)-3-methylenecyclohexanecarboxylate
• CAS No.: 1080621-78-8
• Molecular Formula: C₁₃H₂₂O₃
• Molecular Weight: 226.316
• Mol file: 1080621-78-8.mol

Synonyms:ethyl 1-(2-hydroxypropan-2-yl)-3-methylenecyclohexanecarboxylate

Chemical Property of ethyl 1-(2-hydroxypropan-2-yl)-3-methylenecyclohexanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of ethyl 1-(2-hydroxypropan-2-yl)-3-methylenecyclohexanecarboxylate

There total 2 articles about ethyl 1-(2-hydroxypropan-2-yl)-3-methylenecyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trimethylaluminum (75-24-1) + diethyl 3-methylenecyclohexane-1,1-dicarboxylate (177895-64-6) → ethyl 1-(2-hydroxypropan-2-yl)-3-methylenecyclohexanecarboxylate (1080621-78-8)

Guidance literature:

trimethylaluminum; diethyl 3-methylenecyclohexane-1,1-dicarboxylate; methylaluminoxane; With dibromobis(triphenylphosphine)nickel(II); In toluene; at 20 ℃; for 24h; Inert atmosphere;

With hydrogenchloride; water; In toluene; Inert atmosphere;

DOI:10.1021/ol801728f

Reference yield:

trimethylaluminum (75-24-1) + diethyl 3-methylenecyclohexane-1,1-dicarboxylate (177895-64-6) → ethyl 1-(2-hydroxypropan-2-yl)-3-methylenecyclohexanecarboxylate (1080621-78-8) + diethyl 2-(4-methylenehex-1-yl)malonate (1080621-77-7)

Guidance literature:

trimethylaluminum; diethyl 3-methylenecyclohexane-1,1-dicarboxylate; With dibromobis(triphenylphosphine)nickel(II); In toluene; at 20 ℃; for 24h; Inert atmosphere;

With hydrogenchloride; water; In toluene; Inert atmosphere;

DOI:10.1021/ol801728f

upstream raw materials:

trimethylaluminum

diethyl 3-methylenecyclohexane-1,1-dicarboxylate