Technology Process of {2-formyl-4-[(isobutylamino)carbonyl]penyl}boronic acid
There total 7 articles about {2-formyl-4-[(isobutylamino)carbonyl]penyl}boronic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-bromo-3-(1,3-dioxolan-2-yl)-N-isobutylbenzamide;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 2h;
With
Triisopropyl borate;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 12h;
With
hydrogenchloride;
In
tetrahydrofuran; hexane; water;
at 20 ℃;
for 3h;
DOI:10.1016/j.bmc.2006.08.010
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 4.27 g / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxybenzotriazole / dimethylformamide / 12 h / 20 °C
2.1: MnO2 / CHCl3 / 1 h / 70 °C
3.1: 3.53 g / 4-methylbenzenesulfonic acid monohydrate / toluene / 12 h / Heating
4.1: n-butyl lithium / tetrahydrofuran; hexane / 2 h / -78 °C
4.2: triisopropyl borate / tetrahydrofuran; hexane / 12 h / -78 - 20 °C
4.3: 280 mg / hydrochloric acid / tetrahydrofuran; hexane; H2O / 3 h / 20 °C
With
manganese(IV) oxide; n-butyllithium; p-toluenesulfonic acid monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran; hexane; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2006.08.010
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 3.53 g / 4-methylbenzenesulfonic acid monohydrate / toluene / 12 h / Heating
2.1: n-butyl lithium / tetrahydrofuran; hexane / 2 h / -78 °C
2.2: triisopropyl borate / tetrahydrofuran; hexane / 12 h / -78 - 20 °C
2.3: 280 mg / hydrochloric acid / tetrahydrofuran; hexane; H2O / 3 h / 20 °C
With
n-butyllithium; p-toluenesulfonic acid monohydrate;
In
tetrahydrofuran; hexane; toluene;
DOI:10.1016/j.bmc.2006.08.010
