1β,25-Dihydroxy-6,7-dehydro-3-epiprevitamin D₃

Base Information

Chemical Name:1β,25-Dihydroxy-6,7-dehydro-3-epiprevitamin D₃
CAS No.:146698-80-8
Molecular Formula:C₂₇H₄₂O₃
Molecular Weight:414.629
Hs Code.:

1β,25-Dihydroxy-6,7-dehydro-3-epiprevitamin D<sub>3</sub>

Synonyms:1β,25-Dihydroxy-6,7-dehydro-3-epiprevitamin D₃

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1β,25-Dihydroxy-6,7-dehydro-3-epiprevitamin D₃

Chemical Property:

Purity/Quality:

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Technology Process of 1β,25-Dihydroxy-6,7-dehydro-3-epiprevitamin D₃

There total 7 articles about 1β,25-Dihydroxy-6,7-dehydro-3-epiprevitamin D₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 146698-79-5
1β-<(tert-Butyldimethylsilyl)oxy>-6,7-dehydro-25-hydroxy-3-epiprevitamin D₃ tert-butyldimethylsilyl ether

: 146698-80-8
1β,25-Dihydroxy-6,7-dehydro-3-epiprevitamin D₃

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 12h; Ambient temperature;
DOI:10.1021/jo00059a048

Reference yield:

: 146728-48-5
(3R,5S)-3,5-dihydroxy-1-ethynyl-2-methylcyclohex-1-ene

: 146698-80-8
1β,25-Dihydroxy-6,7-dehydro-3-epiprevitamin D₃

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole / dimethylformamide

2: 79 percent / diethylamine / Pd(PPh₃)2(OAc)2, CuI / dimethylformamide / 1.5 h / Ambient temperature

3: 76 percent / tetrabutylammonium fluoride / tetrahydrofuran / 12 h / Ambient temperature

With 1H-imidazole; tetrabutyl ammonium fluoride; diethylamine; copper(l) iodide; bis(triphenylphosphine) palladium (Il) acetate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo00059a048

Reference yield:

: 146728-46-3
(1R,2S,4R,6R)-2-Ethenyl-2-hydroxy-4-isopropenyl-1-methyl-7-oxabicyclo<4.1.0>heptane

: 146698-80-8
1β,25-Dihydroxy-6,7-dehydro-3-epiprevitamin D₃

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / 4-dimethylaminopyridine, NEt₃

2: 1) ozone 2) p-nitrobenzoyl chloride, pyridine / 1) CH₂Cl₂, MeOH, -78 deg C, 2) CH₂Cl₂

3: SmI₂ / Pd(PPh₃)4

4: NaOMe / methanol / 0 °C

5: imidazole / dimethylformamide

6: 79 percent / diethylamine / Pd(PPh₃)2(OAc)2, CuI / dimethylformamide / 1.5 h / Ambient temperature

7: 76 percent / tetrabutylammonium fluoride / tetrahydrofuran / 12 h / Ambient temperature

With pyridine; 1H-imidazole; dmap; samarium diiodide; tetrabutyl ammonium fluoride; sodium methylate; 4-nitro-benzoyl chloride; ozone; diethylamine; triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(triphenylphosphine) palladium (Il) acetate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo00059a048