2-azido-3,4-O-isopropylidene-1-O-(2,3,4-tri-O-benzyl-6-deoxy-6-[N-(5-dimethylaminonaphth-1-ylsulfonyl)acetamido]-α-D-galactopyranosyl)-D-ribo-octadecane-1,3,4-triol

Base Information

Chemical Name:2-azido-3,4-O-isopropylidene-1-O-(2,3,4-tri-O-benzyl-6-deoxy-6-[N-(5-dimethylaminonaphth-1-ylsulfonyl)acetamido]-α-D-galactopyranosyl)-D-ribo-octadecane-1,3,4-triol
CAS No.:1309598-49-9
Molecular Formula:C₆₂H₈₃N₅O₁₀S
Molecular Weight:1090.43
Hs Code.:

2-azido-3,4-O-isopropylidene-1-O-(2,3,4-tri-O-benzyl-6-deoxy-6-[N-(5-dimethylaminonaphth-1-ylsulfonyl)acetamido]-α-D-galactopyranosyl)-D-ribo-octadecane-1,3,4-triol

Synonyms:2-azido-3,4-O-isopropylidene-1-O-(2,3,4-tri-O-benzyl-6-deoxy-6-[N-(5-dimethylaminonaphth-1-ylsulfonyl)acetamido]-α-D-galactopyranosyl)-D-ribo-octadecane-1,3,4-triol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-azido-3,4-O-isopropylidene-1-O-(2,3,4-tri-O-benzyl-6-deoxy-6-[N-(5-dimethylaminonaphth-1-ylsulfonyl)acetamido]-α-D-galactopyranosyl)-D-ribo-octadecane-1,3,4-triol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-azido-3,4-O-isopropylidene-1-O-(2,3,4-tri-O-benzyl-6-deoxy-6-[N-(5-dimethylaminonaphth-1-ylsulfonyl)acetamido]-α-D-galactopyranosyl)-D-ribo-octadecane-1,3,4-triol

There total 8 articles about 2-azido-3,4-O-isopropylidene-1-O-(2,3,4-tri-O-benzyl-6-deoxy-6-[N-(5-dimethylaminonaphth-1-ylsulfonyl)acetamido]-α-D-galactopyranosyl)-D-ribo-octadecane-1,3,4-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₁H₄₃IN₂O₇S

: 117168-60-2
(2S)-2-azido-2-((4S)-2,2-dimethyl-5-tetradecyl-1,3-dioxolan-4-yl)ethan-1-ol

: 1309598-49-9
2-azido-3,4-O-isopropylidene-1-O-(2,3,4-tri-O-benzyl-6-deoxy-6-[N-(5-dimethylaminonaphth-1-ylsulfonyl)acetamido]-α-D-galactopyranosyl)-D-ribo-octadecane-1,3,4-triol

Guidance literature:: (2S)-2-azido-2-((4S)-2,2-dimethyl-5-tetradecyl-1,3-dioxolan-4-yl)ethan-1-ol; With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In benzene; at 70 ℃; for 0.25h; Molecular sieve; Inert atmosphere;

C₄₁H₄₃IN₂O₇S; In benzene; at 70 ℃; for 20h; Inert atmosphere;
DOI:10.1016/j.carres.2011.02.014

Reference yield:

: Trifluoro-methanesulfonic acid (R)-1-((4R,5R)-2,2-dimethyl-5-tetradecyl-[1,3]dioxolan-4-yl)-2-trityloxy-ethyl ester

: 1309598-49-9
2-azido-3,4-O-isopropylidene-1-O-(2,3,4-tri-O-benzyl-6-deoxy-6-[N-(5-dimethylaminonaphth-1-ylsulfonyl)acetamido]-α-D-galactopyranosyl)-D-ribo-octadecane-1,3,4-triol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium azide / dichloromethane; N,N-dimethyl-formamide / -15 - 20 °C / Inert atmosphere

2.1: triethylsilane; trifluoroacetic acid / dichloromethane / 0 °C / Inert atmosphere

2.2: 0.02 h / 0 °C / Inert atmosphere

3.1: tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine / benzene / 0.25 h / 70 °C / Molecular sieve; Inert atmosphere

3.2: 20 h / 70 °C / Inert atmosphere

With triethylsilane; sodium azide; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/j.carres.2011.02.014

Reference yield:

: 1309598-29-5
methyl 2,3,4-tri-O-benzyl-6-deoxy-6-[N-(5-dimethylaminonaphth-1-ylsulfonyl)amido]-α-D-galactopyranoside

: 1309598-49-9
2-azido-3,4-O-isopropylidene-1-O-(2,3,4-tri-O-benzyl-6-deoxy-6-[N-(5-dimethylaminonaphth-1-ylsulfonyl)acetamido]-α-D-galactopyranosyl)-D-ribo-octadecane-1,3,4-triol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid; acetic anhydride / 3 h / 0 - 20 °C / Inert atmosphere

2.1: trimethylsilyl iodide / dichloromethane / 1 h / 0 °C / Inert atmosphere

3.1: tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine / benzene / 0.25 h / 70 °C / Molecular sieve; Inert atmosphere

3.2: 20 h / 70 °C / Inert atmosphere

With trimethylsilyl iodide; sulfuric acid; acetic anhydride; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane; benzene;
DOI:10.1016/j.carres.2011.02.014