C₆₆H₁₀₁NO₁₁Si₂

Base Information

• Chemical Name: C₆₆H₁₀₁NO₁₁Si₂
• CAS No.: 176656-40-9
• Molecular Formula: C₆₆H₁₀₁NO₁₁Si₂
• Molecular Weight: 1140.7
• Mol file: 176656-40-9.mol

Synonyms:C₆₆H₁₀₁NO₁₁Si₂

Chemical Property of C₆₆H₁₀₁NO₁₁Si₂

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₆H₁₀₁NO₁₁Si₂

There total 14 articles about C₆₆H₁₀₁NO₁₁Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

C69H106INO12Si2 → C66H101NO11Si2 (176656-40-9)

Guidance literature:

With silver(I) acetate; potassium; pyrographite; zinc(II) chloride; In tetrahydrofuran; for 1.5h; Ambient temperature;

DOI:10.1021/jo951646q

Reference yield:

C68H103NO15Si → C66H101NO11Si2 (176656-40-9)

Guidance literature:

Multi-step reaction with 10 steps

1: NaH₂PO₄, NaClO₂ / 2-methyl-propan-2-ol; H₂O; various solvent(s) / 2 h

2: 495 mg / diethyl ether

3: Dess-Martin periodinane / CH₂Cl₂ / 1 h

4: LiOH*H₂O / tetrahydrofuran / 0.5 h

5: 1) TESOTf, 2,6-lutidine, 2) TBAF, AcOH / 1) CH₂Cl₂, 0 deg C, 1h, 2) THF, 0 deg C, 1 h

6: 47.3 mg / 2-chloro-1-methylpyridinium iodide, NET₃ / CH₂Cl₂ / 6 h / Heating

7: 84 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C

8: 83 percent / I₂, PPh₃, imidazole / toluene / 0.5 h / 75 °C

9: 74 percent / 1) KHMDS / tetrahydrofuran; toluene / 1) -78 deg C, 30 min, 2) 30 min

10: 67 percent / graphite, potassium, ZnCl₂, AgOAc / tetrahydrofuran / 1.5 h / Ambient temperature

With 1H-imidazole; 2,6-dimethylpyridine; lithium hydroxide; sodium chlorite; sodium dihydrogenphosphate; tetrabutyl ammonium fluoride; 2-chloro-1-methyl-pyridinium iodide; iodine; triethylsilyl trifluoromethyl sulfonate; silver(I) acetate; potassium; potassium hexamethylsilazane; L-Selectride; pyrographite; Dess-Martin periodane; acetic acid; triethylamine; triphenylphosphine; zinc(II) chloride; In tetrahydrofuran; diethyl ether; dichloromethane; water; toluene; tert-butyl alcohol;

DOI:10.1021/jo951646q

Reference yield:

C68H105NO15Si → C66H101NO11Si2 (176656-40-9)

Guidance literature:

Multi-step reaction with 11 steps

1: NaHCO₃, KBr, 4-methoxy-2,2,6,6-tetramethylpiperidinyloxy free radical, NaOCl / CH₂Cl₂ / 1.33 h / 0 °C

2: NaH₂PO₄, NaClO₂ / 2-methyl-propan-2-ol; H₂O; various solvent(s) / 2 h

3: 495 mg / diethyl ether

4: Dess-Martin periodinane / CH₂Cl₂ / 1 h

5: LiOH*H₂O / tetrahydrofuran / 0.5 h

6: 1) TESOTf, 2,6-lutidine, 2) TBAF, AcOH / 1) CH₂Cl₂, 0 deg C, 1h, 2) THF, 0 deg C, 1 h

7: 47.3 mg / 2-chloro-1-methylpyridinium iodide, NET₃ / CH₂Cl₂ / 6 h / Heating

8: 84 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C

9: 83 percent / I₂, PPh₃, imidazole / toluene / 0.5 h / 75 °C

10: 74 percent / 1) KHMDS / tetrahydrofuran; toluene / 1) -78 deg C, 30 min, 2) 30 min

11: 67 percent / graphite, potassium, ZnCl₂, AgOAc / tetrahydrofuran / 1.5 h / Ambient temperature

With 1H-imidazole; 2,6-dimethylpyridine; lithium hydroxide; sodium hypochlorite; sodium chlorite; sodium dihydrogenphosphate; tetrabutyl ammonium fluoride; 2-chloro-1-methyl-pyridinium iodide; iodine; triethylsilyl trifluoromethyl sulfonate; silver(I) acetate; potassium; potassium hexamethylsilazane; L-Selectride; sodium hydrogencarbonate; pyrographite; Dess-Martin periodane; 4-methoxy-2,2,6,6-tetramethylpiperidin-1-oxyl radical; acetic acid; triethylamine; triphenylphosphine; potassium bromide; zinc(II) chloride; In tetrahydrofuran; diethyl ether; dichloromethane; water; toluene; tert-butyl alcohol;

DOI:10.1021/jo951646q

Downstream raw materials:

Tacrolimus

Refernces