4-(4-bromo-2-methylphenyl)-N-(3-cyano-4-(ethylsulfonyl)phenyl)butanamide

Base Information

Chemical Name:4-(4-bromo-2-methylphenyl)-N-(3-cyano-4-(ethylsulfonyl)phenyl)butanamide
CAS No.:943740-13-4
Molecular Formula:C₂₀H₂₁BrN₂O₃S
Molecular Weight:449.368
Hs Code.:

Synonyms:4-(4-bromo-2-methylphenyl)-N-(3-cyano-4-(ethylsulfonyl)phenyl)butanamide

Suppliers and Price of 4-(4-bromo-2-methylphenyl)-N-(3-cyano-4-(ethylsulfonyl)phenyl)butanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(4-bromo-2-methylphenyl)-N-(3-cyano-4-(ethylsulfonyl)phenyl)butanamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(4-bromo-2-methylphenyl)-N-(3-cyano-4-(ethylsulfonyl)phenyl)butanamide

There total 7 articles about 4-(4-bromo-2-methylphenyl)-N-(3-cyano-4-(ethylsulfonyl)phenyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 918812-59-6
5-amino-2-(ethylsulfonyl)benzonitrile

: 4-(4-bromo-2-methylphenyl)butanoic acid chloride

: 943740-13-4
4-(4-bromo-2-methylphenyl)-N-(3-cyano-4-(ethylsulfonyl)phenyl)butanamide

Guidance literature:: In toluene; for 2h; Heating / reflux;

Reference yield:

: 943740-12-3
4-(4-bromo-2-methylphenyl)butanoic acid

: 943740-13-4
4-(4-bromo-2-methylphenyl)-N-(3-cyano-4-(ethylsulfonyl)phenyl)butanamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 4 h

2: toluene / 2 h / Reflux

With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/acs.jmedchem.5b00788

Reference yield:

: 116632-39-4
2-methyl-4-bromoiodobenzene

: 943740-13-4
4-(4-bromo-2-methylphenyl)-N-(3-cyano-4-(ethylsulfonyl)phenyl)butanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

1.2: 20 - 70 °C / Inert atmosphere

2.1: sodium hydroxide / methanol; tetrahydrofuran / 1 h / 80 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 4 h

4.1: toluene / 2 h / Reflux

With oxalyl dichloride; 9-bora-bicyclo[3.3.1]nonane; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/acs.jmedchem.5b00788