2-(2-Iodo-4,5-dimethoxyphenyl)ethan-1-ol

Base Information

• Chemical Name: 2-(2-Iodo-4,5-dimethoxyphenyl)ethan-1-ol
• CAS No.: 64705-37-9
• Molecular Formula: C10H13 I O3
• Molecular Weight: 308.116
• Hs Code.: 2909499000
• DSSTox Substance ID: DTXSID40479372
• Nikkaji Number: J2.961.046K
• Wikidata: Q82313367
• Mol file: 64705-37-9.mol

Synonyms:64705-37-9;2-(2-Iodo-4,5-dimethoxyphenyl)ethan-1-ol;SCHEMBL25143222;DTXSID40479372;AKOS015967405

Chemical Property of 2-(2-Iodo-4,5-dimethoxyphenyl)ethan-1-ol

Chemical Property:

• Vapor Pressure: 4.09E-06mmHg at 25°C
• Refractive Index: 1.584
• Boiling Point: 369.6°C at 760 mmHg
• Flash Point: 177.3°C
• PSA: 38.69000
• Density: 1.623g/cm³
• LogP: 1.84320
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 307.99094
• Heavy Atom Count: 14
• Complexity: 165

Purity/Quality:

99% ^*data from raw suppliers

2-(2-IODO-4,5-DIMETHOXY-PHENYL)-ETHANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C(=C1)CCO)I)OC

Technology Process of 2-(2-Iodo-4,5-dimethoxyphenyl)ethan-1-ol

There total 5 articles about 2-(2-Iodo-4,5-dimethoxyphenyl)ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-(3,4-dimethoxyphenyl)ethyl alcohol (7417-21-2) → 2-(2-iodo-4,5-dimethoxyphenyl)ethanol (64705-37-9)

Guidance literature:

With iodine; silver trifluoroacetate; In chloroform; at 20 ℃; for 0.5h;

DOI:10.1016/j.tet.2004.10.105

Reference yield:

(2-iodo-4,5-dimethoxyphenyl)acetic acid (35323-09-2) → 2-(2-iodo-4,5-dimethoxyphenyl)ethanol (64705-37-9)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at 25 ℃; for 12h;

DOI:10.1021/ol026128y

Reference yield:

2-iodo-4,5-dimethoxyphenylacetic acid methyl ester (35345-49-4) → 2-(2-iodo-4,5-dimethoxyphenyl)ethanol (64705-37-9)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 6h; Inert atmosphere;

DOI:10.1039/c8cc00001h

upstream raw materials:

2-(3,4-dimethoxyphenyl)ethyl alcohol

(2-iodo-4,5-dimethoxyphenyl)acetic acid

(3,4-Dimethoxyphenyl)acetic acid

2-iodo-4,5-dimethoxyphenylacetic acid methyl ester

Downstream raw materials:

2-Jod-4,5-dimethoxy-phenaethylchlorid

2-(2-iodo-4,5-dimethoxyphenyl)ethyl p-toluenesulfonate

2-{4,5-dimethoxy-2-[(triisopropylsilanyl)ethynyl]phenyl}ethanol

2-(2-iodo-4,5-dimethoxyphenyl)acetaldehyde