7-Deacetyl-1,9-dideoxyforskolin from Coleus forskohlii

Base Information

Chemical Name:7-Deacetyl-1,9-dideoxyforskolin from Coleus forskohlii
CAS No.:64657-19-8
Molecular Formula:C₂₀H₃₂O₄
Molecular Weight:336.472
Hs Code.:
DSSTox Substance ID:DTXSID80546395
Nikkaji Number:J926.972J
Wikidata:Q82424224

Synonyms:64657-19-8;7-Deacetyl-1,9-dideoxyforskolin from Coleus forskohlii;(3R,4aS,5S,6S,6aS,10aS,10bR)-3-ethenyl-5,6-dihydroxy-3,4a,7,7,10a-pentamethyl-2,5,6,6a,8,9,10,10b-octahydrobenzo[f]chromen-1-one;6beta,7beta-Dihydroxy-8,13-epoxy-labd-14-en-11-one;DTXSID80546395;(3R,4aS,5S,6S,6aS,10aS,10bR)-3-ethenyl-5,6-dihydroxy-3,4a,7,7,10a-pentamethyl-dodecahydro-1H-naphtho[2,1-b]pyran-1-one;(3R,4AS,5S,6S,6aS,10aS,10bR)-5,6-dihydroxy-3,4a,7,7,10a-pentamethyl-3-vinyldodecahydro-1H-benzo[f]chromen-1-one;7-Deacetyl-1,9-dideoxyforskolin from Coleus forskohlii, >=98%;(3R,4aS,5S,6S,6aS,10aS,10bR)-3-Ethenyl-5,6-dihydroxy-3,4a,7,7,10a-pentamethyldodecahydro-1H-naphtho[2,1-b]pyran-1-one

Suppliers and Price of 7-Deacetyl-1,9-dideoxyforskolin from Coleus forskohlii

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 7-Deacetyl-1,9-dideoxyforskolin from Coleus forskohlii

Chemical Property:

PSA：66.76000
LogP:2.86340
Storage Temp.:−20°C
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:336.23005950
Heavy Atom Count:24
Complexity:570

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(CCCC2(C1C(C(C3(C2C(=O)CC(O3)(C)C=C)C)O)O)C)C
Isomeric SMILES:C[C@]12CCCC([C@@H]1[C@@H]([C@@H]([C@@]3([C@@H]2C(=O)C[C@](O3)(C)C=C)C)O)O)(C)C

Technology Process of 7-Deacetyl-1,9-dideoxyforskolin from Coleus forskohlii

There total 12 articles about 7-Deacetyl-1,9-dideoxyforskolin from Coleus forskohlii which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 125107-82-6
(2S,7S,13S,6R,9R)-4,4,7,9,13,17,17-heptamethyl-3,5,8-trioxa-9-vinyltetracyclo[11.4.0.0^2,60^7,12]heptadecan-11-one

: 64657-19-8
7-deacetyl-1,9-dideoxyforskolin

Guidance literature:: With perchloric acid; In tetrahydrofuran; at 20 ℃; for 168h;
DOI:10.1016/S0040-4039(03)00236-3

Reference yield:

: 157201-96-2
(1S,7S,9S,3R,5R,8R,14R)-14-acetyloxy-8,9-dihydroxy-1,5,7,11,11-pentamethyl-6-oxa-5-vinyltricyclo[8.4.0.0^2,7]tetradec-3-yl acetate

: 64657-19-8
7-deacetyl-1,9-dideoxyforskolin

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / p-toluenesulfonic acid / 24 h / 50 °C

2: 96 percent / lithium aluminumhydride / diethyl ether / 2.5 h / 20 °C

3: 89 percent / pyridinium chlorochromate; sodium acetate / CH₂Cl₂ / 3 h / 20 °C

4: 82 percent / (dimethylamino)pyridine / diethyl ether / 2.5 h / 50 °C

5: 86 percent / tributyltinhydride; azobisisobutyronitrile / toluene / 0.25 h / 100 °C

6: 100 percent / perchloric acid / tetrahydrofuran / 109 h / 20 °C

With dmap; lithium aluminium tetrahydride; perchloric acid; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium acetate; toluene-4-sulfonic acid; pyridinium chlorochromate; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;
DOI:10.1021/jo060477e

Reference yield:

: ptychantin A

: 64657-19-8
7-deacetyl-1,9-dideoxyforskolin

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / potassium hydroxide / methanol / 13.5 h / 20 °C

2: 93 percent / p-toluenesulfonic acid / 24 h / 50 °C

3: 96 percent / lithium aluminumhydride / diethyl ether / 2.5 h / 20 °C

4: 89 percent / pyridinium chlorochromate; sodium acetate / CH₂Cl₂ / 3 h / 20 °C

5: 82 percent / (dimethylamino)pyridine / diethyl ether / 2.5 h / 50 °C

6: 86 percent / tributyltinhydride; azobisisobutyronitrile / toluene / 0.25 h / 100 °C

7: 100 percent / perchloric acid / tetrahydrofuran / 109 h / 20 °C

With dmap; potassium hydroxide; lithium aluminium tetrahydride; perchloric acid; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium acetate; toluene-4-sulfonic acid; pyridinium chlorochromate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene;
DOI:10.1021/jo060477e