(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-methoxycarbonyl-2-phenylsulfanyl-ethyl ester

Base Information

• Chemical Name: (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-methoxycarbonyl-2-phenylsulfanyl-ethyl ester
• CAS No.: 82971-71-9
• Molecular Formula: C₂₀H₁₉F₃O₅S
• Molecular Weight: 428.429
• Mol file: 82971-71-9.mol

Synonyms:(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-methoxycarbonyl-2-phenylsulfanyl-ethyl ester

Chemical Property of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-methoxycarbonyl-2-phenylsulfanyl-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-methoxycarbonyl-2-phenylsulfanyl-ethyl ester

There total 5 articles about (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-methoxycarbonyl-2-phenylsulfanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-2-Hydroxy-3-(phenylthio)propanoic acid (83023-81-8) → (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-methoxycarbonyl-2-phenylsulfanyl-ethyl ester (82971-71-9)

Guidance literature:

Multi-step reaction with 2 steps

1: acetyl chloride / 2 h / Heating

2: pyridine / CCl₄ / 8 h

With pyridine; acetyl chloride; In tetrachloromethane;

DOI:10.1021/ja00380a021

Reference yield:

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride (39637-99-5,20445-33-4) + (R)-2-Hydroxy-3-phenylsulfanyl-propionic acid methyl ester (111248-06-7) → (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-methoxycarbonyl-2-phenylsulfanyl-ethyl ester (82971-71-9)

Guidance literature:

With pyridine; In tetrachloromethane; for 8h;

DOI:10.1021/ja00380a021

Reference yield:

(2S)-hydroxy-3-(phenylthio)propanoic acid (83023-80-7) → (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-1-methoxycarbonyl-2-phenylsulfanyl-ethyl ester (82044-25-5,82971-70-8,82971-71-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / diethyl ether / 0.5 h / 25 °C

2: DMAP / CH₂Cl₂

With dmap; In diethyl ether; dichloromethane;

DOI:10.1021/jo00038a028

upstream raw materials:

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

(R)-2-Hydroxy-3-phenylsulfanyl-propionic acid methyl ester

(R)-2-Hydroxy-3-(phenylthio)propanoic acid

methyl β-(thiophenoxy)lactate