24-[bis[5'-chloro-4'-hydroxy-3'-(mehoxycarbonyl)phenyl]methylene]-3α,7α,12α-triacetoxycholane

Base Information

Chemical Name:24-[bis[5'-chloro-4'-hydroxy-3'-(mehoxycarbonyl)phenyl]methylene]-3α,7α,12α-triacetoxycholane
CAS No.:397843-12-8
Molecular Formula:C₄₇H₅₈Cl₂O₁₂
Molecular Weight:885.876
Hs Code.:

Synonyms:24-[bis[5'-chloro-4'-hydroxy-3'-(mehoxycarbonyl)phenyl]methylene]-3α,7α,12α-triacetoxycholane

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Chemical Property of 24-[bis[5'-chloro-4'-hydroxy-3'-(mehoxycarbonyl)phenyl]methylene]-3α,7α,12α-triacetoxycholane

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Technology Process of 24-[bis[5'-chloro-4'-hydroxy-3'-(mehoxycarbonyl)phenyl]methylene]-3α,7α,12α-triacetoxycholane

There total 5 articles about 24-[bis[5'-chloro-4'-hydroxy-3'-(mehoxycarbonyl)phenyl]methylene]-3α,7α,12α-triacetoxycholane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 87899-19-2
(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-dimethyl-17-((R)-5-oxopentan-2-yl)hexadecahydro-1H-cyclopenta[a] phenanthrene-3,7,12-triyl triacetate

: 397843-11-7
di[4-acetoxy-3-chloro-5-(methoxycarbonyl)phenyl]ketone

: 397843-12-8
24-[bis[5'-chloro-4'-hydroxy-3'-(mehoxycarbonyl)phenyl]methylene]-3α,7α,12α-triacetoxycholane

Guidance literature:: With tetrachlorobis(tetrahydrofuran)titanium(IV); zinc; In tetrahydrofuran; for 24h; Heating;
DOI:10.1016/S0040-4020(01)00955-3

Reference yield:

: 128626-47-1
3,3'-dichloro-5,5'-dicarboxy-4,4'-dihydroxydiphenylmethane

: 397843-12-8
24-[bis[5'-chloro-4'-hydroxy-3'-(mehoxycarbonyl)phenyl]methylene]-3α,7α,12α-triacetoxycholane

Guidance literature:: Multi-step reaction with 4 steps

1: 45 percent / methanol; benzene; hexane / 10 h

2: 58 percent / pyridine; 4-dimethylaminopyridine / 24 h

3: 97 percent / CrO₃ / acetic anhydride / 12 h / 20 °C

4: 25 percent / TiCl₄*2THF; Zn dust / tetrahydrofuran / 24 h / Heating

With pyridine; chromium(VI) oxide; dmap; tetrachlorobis(tetrahydrofuran)titanium(IV); zinc; In tetrahydrofuran; methanol; hexane; acetic anhydride; benzene; 4: McMurry coupling;
DOI:10.1016/S0040-4020(01)00955-3

Reference yield:

: 20171-56-6
3α,7α,12α-triacetoxy-5β-cholane-24-ol

: 397843-12-8
24-[bis[5'-chloro-4'-hydroxy-3'-(mehoxycarbonyl)phenyl]methylene]-3α,7α,12α-triacetoxycholane

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / Dess-Martin periodinane / CH₂Cl₂ / 2 h

2: 25 percent / TiCl₄*2THF; Zn dust / tetrahydrofuran / 24 h / Heating

With tetrachlorobis(tetrahydrofuran)titanium(IV); Dess-Martin periodane; zinc; In tetrahydrofuran; dichloromethane; 2: McMurry coupling;
DOI:10.1016/S0040-4020(01)00955-3