1-{4-[6-phenyl-2-(1H-pyrazol-4-yl)-pyrrolo[3,2-d]pyrimidin-5-yl]-phenyl}cyclobutylamine

Base Information

Chemical Name:1-{4-[6-phenyl-2-(1H-pyrazol-4-yl)-pyrrolo[3,2-d]pyrimidin-5-yl]-phenyl}cyclobutylamine
CAS No.:1439396-36-7
Molecular Formula:C₂₅H₂₂N₆
Molecular Weight:406.49
Hs Code.:

Synonyms:1-{4-[6-phenyl-2-(1H-pyrazol-4-yl)-pyrrolo[3,2-d]pyrimidin-5-yl]-phenyl}cyclobutylamine

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Chemical Property of 1-{4-[6-phenyl-2-(1H-pyrazol-4-yl)-pyrrolo[3,2-d]pyrimidin-5-yl]-phenyl}cyclobutylamine

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Technology Process of 1-{4-[6-phenyl-2-(1H-pyrazol-4-yl)-pyrrolo[3,2-d]pyrimidin-5-yl]-phenyl}cyclobutylamine

There total 4 articles about 1-{4-[6-phenyl-2-(1H-pyrazol-4-yl)-pyrrolo[3,2-d]pyrimidin-5-yl]-phenyl}cyclobutylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1439396-38-9
(1-{4-[6-phenyl-2-(1H-pyrazol-4-yl)-pyrrolo[3,2-d]pyrimidin-5-yl]-phenyl}-cyclobutyl)-carbamic acid tert-butyl ester

: 1439396-36-7
1-{4-[6-phenyl-2-(1H-pyrazol-4-yl)-pyrrolo[3,2-d]pyrimidin-5-yl]-phenyl}cyclobutylamine

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 0 - 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: 536-74-3
phenylacetylene

: 1439396-36-7
1-{4-[6-phenyl-2-(1H-pyrazol-4-yl)-pyrrolo[3,2-d]pyrimidin-5-yl]-phenyl}cyclobutylamine

Guidance literature:: Multi-step reaction with 4 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 2 h / 100 °C / Inert atmosphere

2: caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere; Microwave irradiation

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

4: hydrogenchloride / ethyl acetate / 4 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; caesium carbonate; triethylamine; XPhos; In 1,4-dioxane; water; ethyl acetate;

Reference yield:

: 1439396-27-6
5-bromo-2-chloro-4-(phenylethynyl)pyrimidine

: 1439396-36-7
1-{4-[6-phenyl-2-(1H-pyrazol-4-yl)-pyrrolo[3,2-d]pyrimidin-5-yl]-phenyl}cyclobutylamine

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere; Microwave irradiation

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

3: hydrogenchloride / ethyl acetate / 4 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos; In 1,4-dioxane; water; ethyl acetate;