1-(3-chloro-2-hydroxyphenyl)-3-(1-methyl-3-propyl-1H-5-pyrazolyl)-1,3-propanedione

Base Information

• Chemical Name: 1-(3-chloro-2-hydroxyphenyl)-3-(1-methyl-3-propyl-1H-5-pyrazolyl)-1,3-propanedione
• CAS No.: 778639-55-7
• Molecular Formula: C₁₆H₁₇ClN₂O₃
• Molecular Weight: 320.776
• Mol file: 778639-55-7.mol

Synonyms:1-(3-chloro-2-hydroxyphenyl)-3-(1-methyl-3-propyl-1H-5-pyrazolyl)-1,3-propanedione

Chemical Property of 1-(3-chloro-2-hydroxyphenyl)-3-(1-methyl-3-propyl-1H-5-pyrazolyl)-1,3-propanedione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-chloro-2-hydroxyphenyl)-3-(1-methyl-3-propyl-1H-5-pyrazolyl)-1,3-propanedione

There total 3 articles about 1-(3-chloro-2-hydroxyphenyl)-3-(1-methyl-3-propyl-1H-5-pyrazolyl)-1,3-propanedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-methyl-5-propyl-2H-pyrazole-3-carboxylic acid 2-acetyl-6-chloro-phenyl ester (778639-42-2) → 1-(3-chloro-2-hydroxyphenyl)-3-(1-methyl-3-propyl-1H-5-pyrazolyl)-1,3-propanedione (778639-55-7)

Guidance literature:

With potassium hydroxide; In pyridine; at 20 ℃; for 3h;

Reference yield:

1-(3-chloro-2-hydroxyphenyl)ethanone (3226-34-4) → 1-(3-chloro-2-hydroxyphenyl)-3-(1-methyl-3-propyl-1H-5-pyrazolyl)-1,3-propanedione (778639-55-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / phosphorous oxychloride / pyridine / 0 - 5 °C

2: 78 percent / potassium hydroxide / pyridine / 3 h / 20 °C

With potassium hydroxide; trichlorophosphate; In pyridine;

Reference yield:

1-methyl-3-propyl-1 H-pyrazole-5-carboxylic acid (139755-99-0) → 1-(3-chloro-2-hydroxyphenyl)-3-(1-methyl-3-propyl-1H-5-pyrazolyl)-1,3-propanedione (778639-55-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / phosphorous oxychloride / pyridine / 0 - 5 °C

2: 78 percent / potassium hydroxide / pyridine / 3 h / 20 °C

With potassium hydroxide; trichlorophosphate; In pyridine;

upstream raw materials:

2-methyl-5-propyl-2H-pyrazole-3-carboxylic acid 2-acetyl-6-chloro-phenyl ester

1-(3-chloro-2-hydroxyphenyl)ethanone

1-methyl-3-propyl-1 H-pyrazole-5-carboxylic acid