2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-3-phenylquinoxaline-6-carboxylic acid

Base Information

• Chemical Name: 2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-3-phenylquinoxaline-6-carboxylic acid
• CAS No.: 612847-31-1
• Molecular Formula: C₃₄H₂₉N₅O₃
• Molecular Weight: 555.636

Synonyms:2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-3-phenylquinoxaline-6-carboxylic acid

Chemical Property of 2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-3-phenylquinoxaline-6-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of 2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-3-phenylquinoxaline-6-carboxylic acid

There total 3 articles about 2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-3-phenylquinoxaline-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-diaminobenzoic acid (619-05-6) + 1-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-2-phenylethane-1,2-dione (612848-74-5) → 3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-2-phenylquinoxaline-6-carboxylic Acid (612847-29-7) + 2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-3-phenylquinoxaline-6-carboxylic acid (612847-31-1)

Guidance literature:

With acetic acid; In ethanol; at 160 ℃; for 0.166667h; microwave irradiation;

DOI:10.1016/j.bmcl.2004.11.011

Reference yield:

(4-(Bromomethyl)phenyl)phenylethanedione (18189-19-0) → 2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-3-phenylquinoxaline-6-carboxylic acid (612847-31-1)

Guidance literature:

Multi-step reaction with 2 steps

1: PS-DIEA / CH₂Cl₂ / 20 °C

2: AcOH / ethanol / 0.17 h / 160 °C / microwave irradiation

With PS-DIEA; acetic acid; In ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2004.11.011

Reference yield:

4-(2-keto-1-benzimidazolinyl)piperidine (20662-53-7) → 2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-3-phenylquinoxaline-6-carboxylic acid (612847-31-1)

Guidance literature:

Multi-step reaction with 2 steps

1: PS-DIEA / CH₂Cl₂ / 20 °C

2: AcOH / ethanol / 0.17 h / 160 °C / microwave irradiation

With PS-DIEA; acetic acid; In ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2004.11.011

upstream raw materials:

3,4-diaminobenzoic acid

1-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-2-phenylethane-1,2-dione

(4-(Bromomethyl)phenyl)phenylethanedione

4-(2-keto-1-benzimidazolinyl)piperidine

Downstream raw materials:

N-[2-(diethylamino)ethyl]-3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-2-phenylquinoxaline-6-carboxamide

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