Technology Process of C18H20BrNO4
There total 4 articles about C18H20BrNO4 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl-4,N(tert-butoxycarbonyl)amino,but-2-ynoate;
With
palladium diacetate; tris(2,6-dimethoxyphenyl)phosphine;
In
toluene;
at 20 ℃;
for 0.166667h;
3-bromophenylacetylene;
In
toluene;
at 20 ℃;
for 6h;
With
palladium(II) trifluoroacetate;
In
toluene;
at 20 ℃;
for 6h;
DOI:10.1021/ja110117g
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C
1.2: 18 h / -78 - 20 °C
2.1: hydrogenchloride; water / tetrahydrofuran; hexane / 1 h / 20 °C
3.1: palladium diacetate; tris(2,6-dimethoxyphenyl)phosphine / toluene / 0.17 h / 20 °C
3.2: 6 h / 20 °C
3.3: 6 h / 20 °C
With
hydrogenchloride; water; palladium diacetate; tris(2,6-dimethoxyphenyl)phosphine; lithium diisopropyl amide;
In
tetrahydrofuran; hexane; toluene;
DOI:10.1021/ja110117g
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C
2.2: 18 h / -78 - 20 °C
3.1: hydrogenchloride; water / tetrahydrofuran; hexane / 1 h / 20 °C
4.1: palladium diacetate; tris(2,6-dimethoxyphenyl)phosphine / toluene / 0.17 h / 20 °C
4.2: 6 h / 20 °C
4.3: 6 h / 20 °C
With
hydrogenchloride; water; palladium diacetate; tris(2,6-dimethoxyphenyl)phosphine; triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran; hexane; dichloromethane; toluene;
DOI:10.1021/ja110117g
