(rac)-2-(4-(tert-butyl)phenyl)-2-hydroxyacetic acid

Base Information

• Chemical Name: (rac)-2-(4-(tert-butyl)phenyl)-2-hydroxyacetic acid
• CAS No.: 100257-22-5
• Molecular Formula: C₁₂H₁₆O₃
• Molecular Weight: 208.257
• Mol file: 100257-22-5.mol

Synonyms:(rac)-2-(4-(tert-butyl)phenyl)-2-hydroxyacetic acid

Chemical Property of (rac)-2-(4-(tert-butyl)phenyl)-2-hydroxyacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (rac)-2-(4-(tert-butyl)phenyl)-2-hydroxyacetic acid

There total 4 articles about (rac)-2-(4-(tert-butyl)phenyl)-2-hydroxyacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

Bromoform (75-25-2) + 4-tert-Butylbenzaldehyde (939-97-9) → (rac)-2-(4-(tert-butyl)phenyl)-2-hydroxyacetic acid (100257-22-5)

Guidance literature:

With lithium chloride; potassium hydroxide; In 1,4-dioxane; at 0 - 35 ℃; for 60h; Reagent/catalyst; Solvent;

DOI:10.1002/ejoc.201700161

Reference yield:

2-(4-(tert-butyl)phenyl)-2-oxoacetic acid (7099-90-3) → (rac)-2-(4-(tert-butyl)phenyl)-2-hydroxyacetic acid (100257-22-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; sodium acetate; triphenylphosphine; In methanol; at 20 ℃; under 7500.75 Torr;

DOI:10.1002/adsc.201700846

Reference yield:

tert-butylbenzene (253185-03-4,253185-04-5) + Diethyl ketomalonate (609-09-6) → (rac)-2-(4-(tert-butyl)phenyl)-2-hydroxyacetic acid (100257-22-5)

Guidance literature:

With tin(IV) chloride; Erwaermen des Reaktionsprodukts mit wss. Kalilauge und Erwaermen der mit wss. Salzsaeure angesaeuerten Reaktionsloesung;

DOI:10.1021/ja01272a008

upstream raw materials:

tert-butylbenzene

Diethyl ketomalonate

Bromoform

4-tert-Butylbenzaldehyde

Refernces

• 1、 Potera?a, Marcin,Dranka, Maciej,Borowiecki, Pawe?. "Chemoenzymatic Preparation of Enantiomerically Enriched (R)-(–)-Mandelic Acid Derivatives: Application in the Synthesis of the Active Agent Pemoline". . p. 2290 - 2304. Retrieved 2017/05/01.