2-(3,5-di-tert-butyl-4-hydroxybenzyl)-5⁽⁶⁾-(4-acetyl-1-piperazinyl)benzimidazole

Base Information

• Chemical Name: 2-(3,5-di-tert-butyl-4-hydroxybenzyl)-5⁽⁶⁾-(4-acetyl-1-piperazinyl)benzimidazole
• CAS No.: 129244-59-3
• Molecular Formula: C₂₈H₃₈N₄O₂
• Molecular Weight: 462.635

Synonyms:2-(3,5-di-tert-butyl-4-hydroxybenzyl)-5⁽⁶⁾-(4-acetyl-1-piperazinyl)benzimidazole

Chemical Property of 2-(3,5-di-tert-butyl-4-hydroxybenzyl)-5⁽⁶⁾-(4-acetyl-1-piperazinyl)benzimidazole

Chemical Property:

Purity/Quality:

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Technology Process of 2-(3,5-di-tert-butyl-4-hydroxybenzyl)-5⁽⁶⁾-(4-acetyl-1-piperazinyl)benzimidazole

There total 3 articles about 2-(3,5-di-tert-butyl-4-hydroxybenzyl)-5⁽⁶⁾-(4-acetyl-1-piperazinyl)benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-(4-(3,4-diaminophenyl)piperazin-1-yl)ethanone (120423-40-7) + 2-methoxyethyl (3,5-di-tert-butyl-4-hydroxyphenyl)acetimidate hydrochloride (136415-07-1) → 2-(3,5-di-tert-butyl-4-hydroxybenzyl)-5(6)-(4-acetyl-1-piperazinyl)benzimidazole (129244-59-3)

Guidance literature:

In acetic acid; for 2h; Heating;

Reference yield:

3-Amino-4-nitro<1-(4-acetylpiperazinyl)>benzene (111861-03-1) → 2-(3,5-di-tert-butyl-4-hydroxybenzyl)-5(6)-(4-acetyl-1-piperazinyl)benzimidazole (129244-59-3)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Ni / dioxane / 760 Torr / Ambient temperature

2: acetic acid / 2 h / Heating

With hydrogen; acetic acid; nickel; In 1,4-dioxane;

DOI:10.1007/BF00769384

Reference yield:

3,5-Di-tert-butyl-4-hydroxyphenylacetonitrile (1611-07-0) → 2-(3,5-di-tert-butyl-4-hydroxybenzyl)-5(6)-(4-acetyl-1-piperazinyl)benzimidazole (129244-59-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / HCl / 48 h / 20 °C

2: 88 percent / acetic acid / 2 h / Heating

With hydrogenchloride; In acetic acid;

upstream raw materials:

1-(4-(3,4-diaminophenyl)piperazin-1-yl)ethanone

2-methoxyethyl (3,5-di-tert-butyl-4-hydroxyphenyl)acetimidate hydrochloride

3,5-Di-tert-butyl-4-hydroxyphenylacetonitrile

3-Amino-4-nitro<1-(4-acetylpiperazinyl)>benzene

Downstream raw materials:

2,6-Di-tert-butyl-4-(5-piperazin-1-yl-1H-benzoimidazol-2-ylmethyl)-phenol

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