(S)-1-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-benzoyl]-pyrrolidine-2-carboxylic acid benzyl ester

Base Information

Chemical Name:(S)-1-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-benzoyl]-pyrrolidine-2-carboxylic acid benzyl ester
CAS No.:361379-64-8
Molecular Formula:C₂₇H₂₂N₂O₅
Molecular Weight:454.482
Hs Code.:

Synonyms:(S)-1-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-benzoyl]-pyrrolidine-2-carboxylic acid benzyl ester

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Chemical Property of (S)-1-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-benzoyl]-pyrrolidine-2-carboxylic acid benzyl ester

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Technology Process of (S)-1-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-benzoyl]-pyrrolidine-2-carboxylic acid benzyl ester

There total 4 articles about (S)-1-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-benzoyl]-pyrrolidine-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 41513-78-4
2-phthalimidobenzoic acid

: 32302-87-7
L?proline benzyl ester p?toluenesulfonate

: 361379-64-8
(S)-1-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-benzoyl]-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;
DOI:10.1055/s-2001-15060

Reference yield:

: 41513-78-4
2-phthalimidobenzoic acid

: 41324-66-7
H-Pro-OBzl

: 361379-64-8
(S)-1-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-benzoyl]-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide;
DOI:10.1002/1521-3773(20010202)40:3<577::AID-ANIE577>3.0.CO;2-L

Reference yield:

: 85-44-9
phthalic anhydride

: 361379-64-8
(S)-1-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-benzoyl]-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 140 °C

2: 92 percent / 1-hydroxybenzotriazol; Et₃N; dicyclohexylcarbodiimide / dimethylformamide

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;
DOI:10.1055/s-2001-15060