4-({2-[1-acetoxy-3-(2-benzyloxycarbonylamino-3-methyl-pentanoylamino)-4-methyl-pentyl]-thiazole-4-carbonyl}-amino)-2-methyl-5-phenyl-pentanoic acid methyl ester

Base Information

Chemical Name:4-({2-[1-acetoxy-3-(2-benzyloxycarbonylamino-3-methyl-pentanoylamino)-4-methyl-pentyl]-thiazole-4-carbonyl}-amino)-2-methyl-5-phenyl-pentanoic acid methyl ester
CAS No.:919518-65-3
Molecular Formula:C₃₉H₅₂N₄O₈S
Molecular Weight:736.93
Hs Code.:

4-({2-[1-acetoxy-3-(2-benzyloxycarbonylamino-3-methyl-pentanoylamino)-4-methyl-pentyl]-thiazole-4-carbonyl}-amino)-2-methyl-5-phenyl-pentanoic acid methyl ester

Synonyms:4-({2-[1-acetoxy-3-(2-benzyloxycarbonylamino-3-methyl-pentanoylamino)-4-methyl-pentyl]-thiazole-4-carbonyl}-amino)-2-methyl-5-phenyl-pentanoic acid methyl ester

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Chemical Property of 4-({2-[1-acetoxy-3-(2-benzyloxycarbonylamino-3-methyl-pentanoylamino)-4-methyl-pentyl]-thiazole-4-carbonyl}-amino)-2-methyl-5-phenyl-pentanoic acid methyl ester

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Technology Process of 4-({2-[1-acetoxy-3-(2-benzyloxycarbonylamino-3-methyl-pentanoylamino)-4-methyl-pentyl]-thiazole-4-carbonyl}-amino)-2-methyl-5-phenyl-pentanoic acid methyl ester

There total 1 articles about 4-({2-[1-acetoxy-3-(2-benzyloxycarbonylamino-3-methyl-pentanoylamino)-4-methyl-pentyl]-thiazole-4-carbonyl}-amino)-2-methyl-5-phenyl-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-({2-[3-(2-benzyloxycarbonylamino-3-methyl-pentanoylamino)-1-hydroxy-4-methyl-pentyl]-thiazole-4-carbonyl}-amino)-2-methyl-5-phenyl-pentanoic acid methyl ester

: 108-24-7
acetic anhydride

: 919518-65-3
4-({2-[1-acetoxy-3-(2-benzyloxycarbonylamino-3-methyl-pentanoylamino)-4-methyl-pentyl]-thiazole-4-carbonyl}-amino)-2-methyl-5-phenyl-pentanoic acid methyl ester

Guidance literature:: With pyridine; at 20 ℃; for 3h;
DOI:10.1002/anie.200601259

Reference yield: 93.0%

: 919518-65-3
4-({2-[1-acetoxy-3-(2-benzyloxycarbonylamino-3-methyl-pentanoylamino)-4-methyl-pentyl]-thiazole-4-carbonyl}-amino)-2-methyl-5-phenyl-pentanoic acid methyl ester

: 943218-34-6
4-({2-[1-acetoxy-3-(2-amino-3-methyl-pentanoylamino)-4-methyl-pentyl]-thiazole-4-carbonyl}-amino)-2-methyl-5-phenyl-pentanoic acid methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1002/anie.200601259

Reference yield:

: 919518-65-3
4-({2-[1-acetoxy-3-(2-benzyloxycarbonylamino-3-methyl-pentanoylamino)-4-methyl-pentyl]-thiazole-4-carbonyl}-amino)-2-methyl-5-phenyl-pentanoic acid methyl ester

: (αS,γR)-γ-[({2-[(1R,3R)-1-hydroxy-4-methyl-3-{[(2S,3S)-3-methyl-2-({[(2R)-1-methylpiperidin-2-yl]carbonyl}amino)-1-oxopentyl]amino}pentyl]-1,3-thiazol-4-yl}carbonyl)amino]-α-methyl-5-phenylpentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / H₂ / Pd/C / methanol

2: 10 percent / iPr₂NEt; 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium*BF₄ / dimethylformamide

3: porcine liver esterase; phosphate buffer / dimethylsulfoxide; H₂O / 4 h / 36 °C / pH 7.3

With porcine liver esterase; phosphate buffer; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/anie.200601259