1'-benzyl-5'-hydroxymethyl-6-methoxy-4-[(methoxymethoxy)methyl]-[2,3']bipyridinyl-1'-ium bromide

Base Information

Chemical Name:1'-benzyl-5'-hydroxymethyl-6-methoxy-4-[(methoxymethoxy)methyl]-[2,3']bipyridinyl-1'-ium bromide
CAS No.:888729-65-5
Molecular Formula:C₂₂H₂₅N₂O₄
Molecular Weight:381.451
Hs Code.:

Synonyms:1'-benzyl-5'-hydroxymethyl-6-methoxy-4-[(methoxymethoxy)methyl]-[2,3']bipyridinyl-1'-ium bromide

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Chemical Property of 1'-benzyl-5'-hydroxymethyl-6-methoxy-4-[(methoxymethoxy)methyl]-[2,3']bipyridinyl-1'-ium bromide

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Technology Process of 1'-benzyl-5'-hydroxymethyl-6-methoxy-4-[(methoxymethoxy)methyl]-[2,3']bipyridinyl-1'-ium bromide

There total 5 articles about 1'-benzyl-5'-hydroxymethyl-6-methoxy-4-[(methoxymethoxy)methyl]-[2,3']bipyridinyl-1'-ium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 888729-53-1
2-chloro-6-methoxy-4-[(methoxymethoxy)methyl]pyridine

: 888729-65-5
1'-benzyl-5'-hydroxymethyl-6-methoxy-4-[(methoxymethoxy)methyl]-[2,3']bipyridinyl-1'-ium bromide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hexabutyldistannane; benzyl-bis-(PPh₃)Pd(II)Cl / dimethylformamide / 5 h / Heating

1.2: 6.750 g / Pd(PPh₃)4 / dimethylformamide / 18 h / 130 °C

2.1: 59 percent / LiAlH₄ / tetrahydrofuran / 3.5 h / -25 - -20 °C

3.1: acetonitrile / 1.75 h / Heating

With lithium aluminium tetrahydride; trans benzyl(chloro)bis(triphenylphosphine)palladium(II); bis(tri-n-butyltin); In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 1.2: Stille coupling;
DOI:10.1021/jm051196m

Reference yield:

: 888729-54-2
6-methoxy-4-[(methoxymethoxy)methyl]-[2,3']bipyridinyl-5'-carboxylic acid methyl ester

: 888729-65-5
1'-benzyl-5'-hydroxymethyl-6-methoxy-4-[(methoxymethoxy)methyl]-[2,3']bipyridinyl-1'-ium bromide

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / LiAlH₄ / tetrahydrofuran / 3.5 h / -25 - -20 °C

2: acetonitrile / 1.75 h / Heating

With lithium aluminium tetrahydride; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm051196m

Reference yield:

: 15855-06-8
2-chloro-6-methoxy-isonicotinic acid

: 888729-65-5
1'-benzyl-5'-hydroxymethyl-6-methoxy-4-[(methoxymethoxy)methyl]-[2,3']bipyridinyl-1'-ium bromide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 85 percent / BH₃*THF / tetrahydrofuran / 5 h / 0 °C

2.1: 95 percent / BF₃*Et₂O / CH₂Cl₂ / 4 h / 20 °C

3.1: hexabutyldistannane; benzyl-bis-(PPh₃)Pd(II)Cl / dimethylformamide / 5 h / Heating

3.2: 6.750 g / Pd(PPh₃)4 / dimethylformamide / 18 h / 130 °C

4.1: 59 percent / LiAlH₄ / tetrahydrofuran / 3.5 h / -25 - -20 °C

5.1: acetonitrile / 1.75 h / Heating

With lithium aluminium tetrahydride; borane-THF; trans benzyl(chloro)bis(triphenylphosphine)palladium(II); boron trifluoride diethyl etherate; bis(tri-n-butyltin); In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 3.2: Stille coupling;
DOI:10.1021/jm051196m