2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-(phenylmethoxy)phenoxy]propoxy]phenoxy]-phenylacetic acid methyl ester

Base Information

Chemical Name:2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-(phenylmethoxy)phenoxy]propoxy]phenoxy]-phenylacetic acid methyl ester
CAS No.:152610-11-2
Molecular Formula:C₄₂H₄₃FO₆
Molecular Weight:662.798
Hs Code.:

Synonyms:2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-(phenylmethoxy)phenoxy]propoxy]phenoxy]-phenylacetic acid methyl ester

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Chemical Property of 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-(phenylmethoxy)phenoxy]propoxy]phenoxy]-phenylacetic acid methyl ester

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Technology Process of 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-(phenylmethoxy)phenoxy]propoxy]phenoxy]-phenylacetic acid methyl ester

There total 10 articles about 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-(phenylmethoxy)phenoxy]propoxy]phenoxy]-phenylacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 152120-11-1
4-(benzyloxy)-5-(4-fluorophenyl)-2-(3-iodopropoxy)ethylbenzene

: 171880-18-5
2-(3-hydroxy-2-propylphenoxy)-phenylacetic acid methyl ester

: 152610-11-2
2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-(phenylmethoxy)phenoxy]propoxy]phenoxy]-phenylacetic acid methyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 24h; Ambient temperature;
DOI:10.1021/jm00022a006

Reference yield:

: 29682-12-0
1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone

: 152610-11-2
2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-(phenylmethoxy)phenoxy]propoxy]phenoxy]-phenylacetic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / K₂CO₃ / dimethylsulfoxide; butan-2-one / 24 h / Heating

2: 69 percent / trifluoroacetic acid, triethylsilane / CCl₄ / 1.5 h / Ambient temperature

3: 73 percent / N-bromosuccinimide / CCl₄ / 6 h / Ambient temperature

4: 84 percent / Pd(PPh₃)4, aq. Na₂CO₃ / ethanol; benzene / 16 h / Heating

5: 100 percent / NaI / butan-2-one / 6 h / Heating

6: 45 percent / K₂CO₃ / dimethylformamide / 24 h / Ambient temperature

With triethylsilane; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; trifluoroacetic acid; sodium iodide; In tetrachloromethane; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; butanone; benzene;
DOI:10.1021/jm00022a006

Reference yield:

: 13331-19-6
2-propyl-1,3-benzenediol

: 152610-11-2
2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-(phenylmethoxy)phenoxy]propoxy]phenoxy]-phenylacetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 11 percent / copper bronze, K₂CO₃ / pyridine / 6 h / Heating

2: 45 percent / K₂CO₃ / dimethylformamide / 24 h / Ambient temperature

With copper; potassium carbonate; In pyridine; N,N-dimethyl-formamide;
DOI:10.1021/jm00022a006