1-(3-hydroxybenzyl)-1H-1,2,3-triazole-4-carboxylic acid

Base Information

Chemical Name:1-(3-hydroxybenzyl)-1H-1,2,3-triazole-4-carboxylic acid
CAS No.:1540431-13-7
Molecular Formula:C₁₀H₉N₃O₃
Molecular Weight:219.2
Hs Code.:

Synonyms:1-(3-hydroxybenzyl)-1H-1,2,3-triazole-4-carboxylic acid

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Chemical Property of 1-(3-hydroxybenzyl)-1H-1,2,3-triazole-4-carboxylic acid

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Technology Process of 1-(3-hydroxybenzyl)-1H-1,2,3-triazole-4-carboxylic acid

There total 5 articles about 1-(3-hydroxybenzyl)-1H-1,2,3-triazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1609429-01-7
methyl 1-(3-acetoxybenzyl)-1H-1,2,3-triazole-4-carboxylate

: 1540431-13-7
1-(3-hydroxybenzyl)-1H-1,2,3-triazole-4-carboxylic acid

Guidance literature:: methyl 1-(3-acetoxybenzyl)-1H-1,2,3-triazole-4-carboxylate; With sodium hydroxide; In methanol; water; at 20 ℃; Inert atmosphere;

With hydrogenchloride; In water; pH=5 - Ca. 6; Inert atmosphere;
DOI:10.1021/jm5001453

Reference yield:

: 49617-80-3
m-(bromomethyl)phenyl acetate

: 1540431-13-7
1-(3-hydroxybenzyl)-1H-1,2,3-triazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium azide / tetrahydrofuran / Inert atmosphere

2.1: copper(II) sulfate; sodium L-ascorbate; bathophenanthrolinedispufonic acid disodium salt / water; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

3.1: sodium hydroxide / water; methanol / 20 °C / Inert atmosphere

3.2: pH 5 - Ca_. 6 / Inert atmosphere

With sodium azide; bathophenanthrolinedispufonic acid disodium salt; copper(II) sulfate; sodium L-ascorbate; sodium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm5001453

Reference yield:

: 874-98-6
1-bromomethyl-3-methoxybenzene

: 1540431-13-7
1-(3-hydroxybenzyl)-1H-1,2,3-triazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: boron tribromide / dichloromethane / 2.5 h / -78 - 0 °C / Inert atmosphere

2.1: sulfuric acid / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

3.1: sodium azide / tetrahydrofuran / Inert atmosphere

4.1: copper(II) sulfate; sodium L-ascorbate; bathophenanthrolinedispufonic acid disodium salt / water; N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

5.1: sodium hydroxide / water; methanol / 20 °C / Inert atmosphere

5.2: pH 5 - Ca_. 6 / Inert atmosphere

With sodium azide; sulfuric acid; bathophenanthrolinedispufonic acid disodium salt; boron tribromide; copper(II) sulfate; sodium L-ascorbate; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm5001453