(S)-2-[(S)-3-(4-but-3-enyloxyphenyl)-2-tert-butoxycarbonylaminopropionylamino]-4-methylpentanoic acid methyl ester

Base Information

Chemical Name:(S)-2-[(S)-3-(4-but-3-enyloxyphenyl)-2-tert-butoxycarbonylaminopropionylamino]-4-methylpentanoic acid methyl ester
CAS No.:1020257-35-5
Molecular Formula:C₂₅H₃₈N₂O₆
Molecular Weight:462.587
Hs Code.:

Synonyms:(S)-2-[(S)-3-(4-but-3-enyloxyphenyl)-2-tert-butoxycarbonylaminopropionylamino]-4-methylpentanoic acid methyl ester

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Chemical Property of (S)-2-[(S)-3-(4-but-3-enyloxyphenyl)-2-tert-butoxycarbonylaminopropionylamino]-4-methylpentanoic acid methyl ester

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Technology Process of (S)-2-[(S)-3-(4-but-3-enyloxyphenyl)-2-tert-butoxycarbonylaminopropionylamino]-4-methylpentanoic acid methyl ester

There total 3 articles about (S)-2-[(S)-3-(4-but-3-enyloxyphenyl)-2-tert-butoxycarbonylaminopropionylamino]-4-methylpentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1020257-34-4
(S)-3-(4-but-3-enyloxy-phenyl)-2-tert-butoxycarbonylamino-propionic acid

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 1020257-35-5
(S)-2-[(S)-3-(4-but-3-enyloxyphenyl)-2-tert-butoxycarbonylaminopropionylamino]-4-methylpentanoic acid methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1002/anie.200805014

Reference yield:

: 1020257-33-3
(S)-3-(4-but-3-enyloxy-phenyl)-2-tert-butoxycarbonylamino-propionic acid methyl ester

: 1020257-35-5
(S)-2-[(S)-3-(4-but-3-enyloxyphenyl)-2-tert-butoxycarbonylaminopropionylamino]-4-methylpentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / tetrahydrofuran; water; methanol / 18 h / 20 °C

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 4326-36-7
(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

: 1020257-35-5
(S)-2-[(S)-3-(4-but-3-enyloxyphenyl)-2-tert-butoxycarbonylaminopropionylamino]-4-methylpentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

2: sodium hydroxide / tetrahydrofuran; water; methanol / 18 h / 20 °C

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;