N-((S)-1-((3R,3aR,6aR)-3-hydroxydihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide

Base Information

Chemical Name:N-((S)-1-((3R,3aR,6aR)-3-hydroxydihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide
CAS No.:1001614-46-5
Molecular Formula:C₂₅H₃₈N₄O₄
Molecular Weight:458.601
Hs Code.:

Synonyms:N-((S)-1-((3R,3aR,6aR)-3-hydroxydihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide

Suppliers and Price of N-((S)-1-((3R,3aR,6aR)-3-hydroxydihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-((S)-1-((3R,3aR,6aR)-3-hydroxydihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-((S)-1-((3R,3aR,6aR)-3-hydroxydihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide

There total 12 articles about N-((S)-1-((3R,3aR,6aR)-3-hydroxydihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: ⁽⁵⁾-2-amino-1-((3R,3aR,6aR)-3-hydroxydihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethylpentan-1-one hydrochloride

: 1001614-46-5
N-((S)-1-((3R,3aR,6aR)-3-hydroxydihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide

Guidance literature:: 4-(4-methylpiperazin-1-yI)benzoic acid; With 4-methyl-morpholine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; for 0.283333h; Sonication;

⁽⁵⁾-2-amino-1-((3R,3aR,6aR)-3-hydroxydihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethylpentan-1-one hydrochloride; In N,N-dimethyl-formamide; for 3.33333h;

Reference yield:

: 1001547-72-3
(3S,3aS,6S,6aS)-6-bromohexahydrofuro[3,2-b]furan-3-yI 4-methylbenzenesulfonate

: 1001614-46-5
N-((S)-1-((3R,3aR,6aR)-3-hydroxydihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: ammonium chloride; zinc / tetrahydrofuran; water / 16 h

2.1: ammonia / water; isopropyl alcohol / 16 h / 75 °C

3.1: sodium carbonate / 1,4-dioxane; water / 0.92 - 1 h / 0 °C

4.1: pyridine / 19.5 h / 14 - 24 °C

5.1: dihydrogen peroxide / methanol; water; acetonitrile / 192 h

6.1: hydrogen / palladium 10% on activated carbon / ethanol / 4.5 h

7.1: sodium carbonate / 1,4-dioxane; water / 2.27 h

8.1: lithium triethylborohydride / tetrahydrofuran / 2 h / 40 °C

9.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

10.1: N,N-dimethyl-formamide / 5.25 h

10.2: 0.27 h

11.1: hydrogenchloride / 1,4-dioxane / 2.08 h

12.1: 4-methyl-morpholine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.28 h / Sonication

12.2: 3.33 h

With 4-methyl-morpholine; pyridine; hydrogenchloride; ammonia; hydrogen; dihydrogen peroxide; lithium triethylborohydride; sodium carbonate; ammonium chloride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; zinc; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 1001547-78-9
(R)-2-(benzyloxycarbonylamino)-1-((S)-2,5-dihydrofuran-2-yI) ethyl 4-methyl benzenesulfonate

: 1001614-46-5
N-((S)-1-((3R,3aR,6aR)-3-hydroxydihydro-2H-furo[3,2-b]pyrrol-4(5H,6H,6aH)-yl)-4,4-dimethyl-1-oxopentan-2-yl)-4-(4-methylpiperazin-1-yl)benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: dihydrogen peroxide / methanol; water; acetonitrile / 192 h

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 4.5 h

3.1: sodium carbonate / 1,4-dioxane; water / 2.27 h

4.1: lithium triethylborohydride / tetrahydrofuran / 2 h / 40 °C

5.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

6.1: N,N-dimethyl-formamide / 5.25 h

6.2: 0.27 h

7.1: hydrogenchloride / 1,4-dioxane / 2.08 h

8.1: 4-methyl-morpholine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.28 h / Sonication

8.2: 3.33 h

With 4-methyl-morpholine; hydrogenchloride; hydrogen; dihydrogen peroxide; lithium triethylborohydride; sodium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;