2-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)ethynyl)-N-tert-butylbenzenesulfonamide

Base Information

Chemical Name:2-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)ethynyl)-N-tert-butylbenzenesulfonamide
CAS No.:1147014-47-8
Molecular Formula:C₁₈H₁₈N₄O₂S
Molecular Weight:354.433
Hs Code.:

Synonyms:2-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)ethynyl)-N-tert-butylbenzenesulfonamide

Suppliers and Price of 2-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)ethynyl)-N-tert-butylbenzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)ethynyl)-N-tert-butylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)ethynyl)-N-tert-butylbenzenesulfonamide

There total 3 articles about 2-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)ethynyl)-N-tert-butylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1147014-46-7
N-tert-butyl-2-ethynylbenzenesulfonamide

: 3680-69-1
4-chloro-1H-pyrrolo[2,3-d]pyrimidine

: 1147014-47-8
2-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)ethynyl)-N-tert-butylbenzenesulfonamide

Guidance literature:: 4-chloro-1H-pyrrolo[2,3-d]pyrimidine; With triethylamine; bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine; In tetrahydrofuran; for 0.25h;

N-tert-butyl-2-ethynylbenzenesulfonamide; copper(l) iodide; In tetrahydrofuran; for 2h; Heating / reflux;

Reference yield:

: 146720-72-1
N-tert-butyl-2-iodobenzenesulphonamide

: 1147014-47-8
2-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)ethynyl)-N-tert-butylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine / tetrahydrofuran / 0.25 h

1.2: 2 h / Heating / reflux

2.1: methanol; potassium hydroxide / 1 h / 20 °C

3.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine / tetrahydrofuran / 0.25 h

3.2: 2 h / Heating / reflux

With methanol; potassium hydroxide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine; In tetrahydrofuran;

Reference yield:

: 1147014-45-6
N-tert-butyl-2-((trimethylsilyl)ethynyl)benzenesulfonamide

: 1147014-47-8
2-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)ethynyl)-N-tert-butylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol; potassium hydroxide / 1 h / 20 °C

2.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine / tetrahydrofuran / 0.25 h

2.2: 2 h / Heating / reflux

With methanol; potassium hydroxide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine; In tetrahydrofuran;