(2S,7R)-2-(2-chlorophenyl)-7-(4-fluorophenyl)-1-methyl-4-[(4-nitrobenzene)sulfonyl]-1,4-diazepane

Base Information

Chemical Name:(2S,7R)-2-(2-chlorophenyl)-7-(4-fluorophenyl)-1-methyl-4-[(4-nitrobenzene)sulfonyl]-1,4-diazepane
CAS No.:1589599-36-9
Molecular Formula:C₂₄H₂₃ClFN₃O₄S
Molecular Weight:503.982
Hs Code.:

Synonyms:(2S,7R)-2-(2-chlorophenyl)-7-(4-fluorophenyl)-1-methyl-4-[(4-nitrobenzene)sulfonyl]-1,4-diazepane

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Chemical Property of (2S,7R)-2-(2-chlorophenyl)-7-(4-fluorophenyl)-1-methyl-4-[(4-nitrobenzene)sulfonyl]-1,4-diazepane

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Technology Process of (2S,7R)-2-(2-chlorophenyl)-7-(4-fluorophenyl)-1-methyl-4-[(4-nitrobenzene)sulfonyl]-1,4-diazepane

There total 10 articles about (2S,7R)-2-(2-chlorophenyl)-7-(4-fluorophenyl)-1-methyl-4-[(4-nitrobenzene)sulfonyl]-1,4-diazepane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: C₂₄H₂₅ClFN₃O₅S

: 1589599-36-9
(2S,7R)-2-(2-chlorophenyl)-7-(4-fluorophenyl)-1-methyl-4-[(4-nitrobenzene)sulfonyl]-1,4-diazepane

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 18h;
DOI:10.1039/c3ob42512f

Reference yield:

: 254967-36-7
3-amino-1-(4-fluorophenyl)-propan-1-ol

: 1589599-36-9
(2S,7R)-2-(2-chlorophenyl)-7-(4-fluorophenyl)-1-methyl-4-[(4-nitrobenzene)sulfonyl]-1,4-diazepane

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 15 h

2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

2.2: 20 h

3.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 18 h

With sodium hydride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c3ob42512f

Reference yield:

: 1213855-02-7
(2S)-2-(2-chlorophenyl)-2-(methylamino)ethan-1-ol

: 1589599-36-9
(2S,7R)-2-(2-chlorophenyl)-7-(4-fluorophenyl)-1-methyl-4-[(4-nitrobenzene)sulfonyl]-1,4-diazepane

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride; triethylamine; 1H-imidazole / dichloromethane / -60 - 20 °C

2.1: ruthenium(III) chloride trihydrate; sodium periodate / acetonitrile; water / 2 h / 0 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h

3.2: 20 h

4.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 18 h

With 1H-imidazole; sodium periodate; thionyl chloride; ruthenium(III) chloride trihydrate; sodium hydride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c3ob42512f