N-[3-(1-trityl-1H-imidazol-4-yl)prop-2-enyl]-4-bromo-1H-pyrrole-2-carboxamide Z

Base Information

Chemical Name:N-[3-(1-trityl-1H-imidazol-4-yl)prop-2-enyl]-4-bromo-1H-pyrrole-2-carboxamide Z
CAS No.:192197-39-0
Molecular Formula:C₃₀H₂₅BrN₄O
Molecular Weight:537.459
Hs Code.:

Synonyms:N-[3-(1-trityl-1H-imidazol-4-yl)prop-2-enyl]-4-bromo-1H-pyrrole-2-carboxamide Z

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Chemical Property of N-[3-(1-trityl-1H-imidazol-4-yl)prop-2-enyl]-4-bromo-1H-pyrrole-2-carboxamide Z

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Technology Process of N-[3-(1-trityl-1H-imidazol-4-yl)prop-2-enyl]-4-bromo-1H-pyrrole-2-carboxamide Z

There total 1 articles about N-[3-(1-trityl-1H-imidazol-4-yl)prop-2-enyl]-4-bromo-1H-pyrrole-2-carboxamide Z which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 138408-51-2
3-(1-trityl-1H-imidazol-4-yl)prop-2-enamine

: 192197-56-1
4-bromo-1H-pyrrole-2-carboxylic acid chloride

: 192197-39-0
N-[3-(1-trityl-1H-imidazol-4-yl)prop-2-enyl]-4-bromo-1H-pyrrole-2-carboxamide Z

Guidance literature:: With triethylamine; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1016/S0040-4020(97)00452-3

Reference yield:

: 192197-39-0
N-[3-(1-trityl-1H-imidazol-4-yl)prop-2-enyl]-4-bromo-1H-pyrrole-2-carboxamide Z

: 192197-45-8
N-[3-(2-amino-1-trityl-1H-imidazol-4-yl)prop-2-enyl]4-bromo-1H-pyrrole-2-carboxamide Z

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi, diisopropylamine, 2.) TsN₃ / 1.) THF, ambient temp., 30 min, 2.) THF, -70 deg C

2: 51 percent / Et₃N, 1,3-propanedithiol / methanol / 3 h / Ambient temperature

With 1.3-propanedithiol; n-butyllithium; 4-toluenesulfonyl azide; triethylamine; diisopropylamine; In methanol;
DOI:10.1016/S0040-4020(97)00452-3

Reference yield:

: 192197-39-0
N-[3-(1-trityl-1H-imidazol-4-yl)prop-2-enyl]-4-bromo-1H-pyrrole-2-carboxamide Z

: 192197-42-5
N-[3-(2-azido-1-trityl-1H-imidazol-4-yl)prop-2-enyl]4-bromo-1H-pyrrole-2-carboxamide Z

Guidance literature:: With n-butyllithium; 4-toluenesulfonyl azide; diisopropylamine; Yield given. Multistep reaction; 1.) THF, ambient temp., 30 min, 2.) THF, -70 deg C;
DOI:10.1016/S0040-4020(97)00452-3