2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetic acid

Base Information

• Chemical Name: 2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetic acid
• CAS No.: 1242849-98-4
• Molecular Formula: C₁₈H₂₂N₂O₅S
• Molecular Weight: 378.449
• Mol file: 1242849-98-4.mol

Synonyms:2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetic acid

Chemical Property of 2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetic acid

There total 7 articles about 2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H26N2O5S (1242850-15-2) → 2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetic acid (1242849-98-4)

Guidance literature:

C₂₀H₂₆N₂O₅S; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 3h;

With potassium hydrogensulfate; In water; at 0 ℃;

Reference yield:

1-(2-aminoethyl)pyrrole (29709-35-1) → 2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetic acid (1242849-98-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2.1: polyphosphoric acid / 5 h / 90 °C

3.1: hydrogen / palladium on activated charcoal / ethanol / 20 °C / 1500.15 Torr

4.1: triethylamine / dichloromethane / 20 °C

5.1: water; sodium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C

5.2: 0 °C

With 1-hydroxy-7-aza-benzotriazole; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane;

Reference yield:

C11H14N2O2 (1242850-13-0) → 2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetic acid (1242849-98-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogen / palladium on activated charcoal / ethanol / 20 °C / 1500.15 Torr

2.1: triethylamine / dichloromethane / 20 °C

3.1: water; sodium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C

3.2: 0 °C

With water; hydrogen; triethylamine; sodium hydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane;

upstream raw materials:

C₂₀H₂₆N₂O₅S

1-(2-aminoethyl)pyrrole

C₁₁H₁₆N₂O₃

C₁₁H₁₆N₂O₂

Downstream raw materials:

1-(4-hydroxy-4-pyridin-3-ylpiperidin-1-yl)-2-[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl]ethanone

2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone

2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)-1-(2-(pyrdin-4-yl)-2,8-diazaspiro[4.5]decan-8-yl)ethanone

C₃₂H₄₂N₄O₄S