N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-8-(tetrahydro-2H-pyran-2-yloxy)octanamide

Base Information

Chemical Name:N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-8-(tetrahydro-2H-pyran-2-yloxy)octanamide
CAS No.:1019975-82-6
Molecular Formula:C₂₂H₂₉F₃N₂O₄
Molecular Weight:442.478
Hs Code.:

Synonyms:N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-8-(tetrahydro-2H-pyran-2-yloxy)octanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-8-(tetrahydro-2H-pyran-2-yloxy)octanamide

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Technology Process of N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-8-(tetrahydro-2H-pyran-2-yloxy)octanamide

There total 1 articles about N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-8-(tetrahydro-2H-pyran-2-yloxy)octanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 37935-47-0
2-(5-bromopentyloxy)tetrahydropyran

: 90357-51-0
N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide

: 1019975-82-6
N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-8-(tetrahydro-2H-pyran-2-yloxy)octanamide

Guidance literature:: 2-(5-bromopentyloxy)tetrahydropyran; With iodine; magnesium; In tetrahydrofuran; at 50 ℃; for 1h;

With thien-2-yl(cyano)copper lithium; In tetrahydrofuran; at -55 ℃; for 0.5h;

N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide; With ammonia; ammonium chloride; more than 3 stages;