methyl 2-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazolin-3(4H)-yl)acetate

Base Information

Chemical Name:methyl 2-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazolin-3(4H)-yl)acetate
CAS No.:1625669-68-2
Molecular Formula:C₂₅H₂₀F₃N₃O₄
Molecular Weight:483.447
Hs Code.:

Synonyms:methyl 2-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazolin-3(4H)-yl)acetate

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Chemical Property of methyl 2-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazolin-3(4H)-yl)acetate

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Technology Process of methyl 2-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazolin-3(4H)-yl)acetate

There total 11 articles about methyl 2-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazolin-3(4H)-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1625675-73-1
4-(2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4,5,6,7,8-octahydroquinazolin-4-yl)-benzonitrile

: 96-32-2
bromoacetic acid methyl ester

: 1625669-68-2
methyl 2-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazolin-3(4H)-yl)acetate

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; at 0 - 10 ℃; Cooling with ice;

Reference yield:

: 105-07-7
4-cyanobenzaldehyde

: 1625669-68-2
methyl 2-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazolin-3(4H)-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: chloro-trimethyl-silane / N,N-dimethyl-formamide; acetonitrile / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 20 °C

3: sodium t-butanolate / acetonitrile / 0.33 h

4: lithium diisopropyl amide / N,N-dimethyl-formamide; acetonitrile; tetrahydrofuran / 0 - 10 °C / Cooling with ice

With chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 51924-57-3
3-[3-(trifluoromethyl)phenyl]aminocyclohex-2-en-1-one

: 1625669-68-2
methyl 2-(4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazolin-3(4H)-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 4 h / Reflux

2: lithium diisopropyl amide / N,N-dimethyl-formamide; acetonitrile; tetrahydrofuran / 0 - 10 °C / Cooling with ice

With lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;