N-hydroxy-2-(2-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)pentan-3-yl)oxazol-4-yl)acetamide

Base Information

• Chemical Name: N-hydroxy-2-(2-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)pentan-3-yl)oxazol-4-yl)acetamide
• CAS No.: 1445853-53-1
• Molecular Formula: C₂₃H₃₄N₂O₅
• Molecular Weight: 418.533
• Mol file: 1445853-53-1.mol

Synonyms:N-hydroxy-2-(2-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)pentan-3-yl)oxazol-4-yl)acetamide

Chemical Property of N-hydroxy-2-(2-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)pentan-3-yl)oxazol-4-yl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-hydroxy-2-(2-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)pentan-3-yl)oxazol-4-yl)acetamide

There total 11 articles about N-hydroxy-2-(2-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)pentan-3-yl)oxazol-4-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

ethyl 2-(2-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)pentan-3-yl)oxazol-4-yl)acetate (1445853-88-2) → N-hydroxy-2-(2-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)pentan-3-yl)oxazol-4-yl)acetamide (1445853-53-1)

Guidance literature:

With ammonium hydroxide; potassium hydroxide; In tetrahydrofuran; methanol; water; at 0 - 20 ℃; for 50h; Inert atmosphere;

Reference yield:

1-chloro-3,3-dimethyl-butan-2-one (13547-70-1) → N-hydroxy-2-(2-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)pentan-3-yl)oxazol-4-yl)acetamide (1445853-53-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 24 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate; ethanol / 1.5 h / 0 - 20 °C / Inert atmosphere

3: potassium hydroxide; ammonium hydroxide / tetrahydrofuran; methanol; water / 50 h / 0 - 20 °C / Inert atmosphere

With ammonium hydroxide; sodium tetrahydroborate; ethanol; potassium carbonate; potassium hydroxide; In tetrahydrofuran; methanol; water; acetonitrile;

Reference yield:

4-Bromo-2-methylphenol (2362-12-1) → N-hydroxy-2-(2-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)pentan-3-yl)oxazol-4-yl)acetamide (1445853-53-1)

Guidance literature:

Multi-step reaction with 10 steps

1.1: potassium carbonate / acetonitrile / 24 h / 20 °C / Inert atmosphere

2.1: N-cyclohexyl-cyclohexanamine; n-butyllithium / toluene; hexane / 0.5 h / 0 °C / Inert atmosphere

2.2: 16 h / Inert atmosphere

3.1: water; sodium hydroxide / methanol / 48 h / Inert atmosphere; Reflux

4.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

5.1: ammonium hydroxide / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

6.1: N,N-dimethyl-formamide / 12 h / 135 °C / Inert atmosphere

7.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate

8.1: potassium carbonate / acetonitrile / 24 h / 20 °C / Inert atmosphere

9.1: sodium tetrahydroborate; ethanol / 1.5 h / 0 - 20 °C / Inert atmosphere

10.1: potassium hydroxide; ammonium hydroxide / tetrahydrofuran; methanol; water / 50 h / 0 - 20 °C / Inert atmosphere

With ammonium hydroxide; sodium tetrahydroborate; n-butyllithium; oxalyl dichloride; ethanol; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; N-cyclohexyl-cyclohexanamine; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;

upstream raw materials:

1-chloro-3,3-dimethyl-butan-2-one

4-Bromo-2-methylphenol

2-(4-benzyloxy-3-methyl-phenyl)-2-ethyl-butyryl chloride

1-(benzyloxy)-4-bromo-2-methylbenzene