6-<3-Chlor-1-ethyl-6-methoxy-2-(4-methoxyphenyl)-indol-5-yl>-hexan-1-al

Base Information

Chemical Name:6-<3-Chlor-1-ethyl-6-methoxy-2-(4-methoxyphenyl)-indol-5-yl>-hexan-1-al
CAS No.:157977-20-3
Molecular Formula:C₂₄H₂₈ClNO₃
Molecular Weight:413.944
Hs Code.:

Synonyms:6-<3-Chlor-1-ethyl-6-methoxy-2-(4-methoxyphenyl)-indol-5-yl>-hexan-1-al

Suppliers and Price of 6-<3-Chlor-1-ethyl-6-methoxy-2-(4-methoxyphenyl)-indol-5-yl>-hexan-1-al

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Chemical Property of 6-<3-Chlor-1-ethyl-6-methoxy-2-(4-methoxyphenyl)-indol-5-yl>-hexan-1-al

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Technology Process of 6-<3-Chlor-1-ethyl-6-methoxy-2-(4-methoxyphenyl)-indol-5-yl>-hexan-1-al

There total 8 articles about 6-<3-Chlor-1-ethyl-6-methoxy-2-(4-methoxyphenyl)-indol-5-yl>-hexan-1-al which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 157977-19-0
6-<3-Chlor-1-ethyl-6-methoxy-2-(4-methoxyphenyl)-indol-5-yl>-hexansaeure-Ethylester

: 157977-20-3
6-<3-Chlor-1-ethyl-6-methoxy-2-(4-methoxyphenyl)-indol-5-yl>-hexan-1-al

Guidance literature:: With C₆H₁₄; diisobutylaluminium hydride; In toluene; at -78 ℃; for 1h;
DOI:10.1002/ardp.19943270602

Reference yield:

: 1071-71-2
ethyl 6-chloro-6-oxohexanoate

: 157977-20-3
6-<3-Chlor-1-ethyl-6-methoxy-2-(4-methoxyphenyl)-indol-5-yl>-hexan-1-al

Guidance literature:: Multi-step reaction with 5 steps

1: 55 percent / AlCl₃ / CH₂Cl₂ / 1 h

2: 84 percent / NaBH₄ / methanol / 0 deg C to r.t.

3: 84 percent / 1.) (C₆H₅)3SiH, CF₃COOH / CH₂Cl₂ / 24 h / Ambient temperature

4: 1.) 80percent NaH / 1.) DMF, paraffin, r.t., 1 h, 2.) DMF, paraffin, 1 h

5: 71 percent / 1.0M DIBAH/C₆H₁₄ / toluene / 1 h / -78 °C

With sodium tetrahydroborate; aluminium trichloride; C₆H₁₄; sodium hydride; diisobutylaluminium hydride; trifluoroacetic acid; HSiPh₃; In methanol; dichloromethane; toluene;
DOI:10.1002/ardp.19943270602

Reference yield:

: 62655-56-5
2-(4'-methoxy-phenyl)-6-methoxy-indole

: 157977-20-3
6-<3-Chlor-1-ethyl-6-methoxy-2-(4-methoxyphenyl)-indol-5-yl>-hexan-1-al

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) 1.6M n-BuLi / 1.) THF, C₆H₁₄, -78 deg C, 3 h, 2.) THF, C₆H₁₄, -78 deg C to r.t., overnight

2: 55 percent / AlCl₃ / CH₂Cl₂ / 1 h

3: 84 percent / NaBH₄ / methanol / 0 deg C to r.t.

4: 84 percent / 1.) (C₆H₅)3SiH, CF₃COOH / CH₂Cl₂ / 24 h / Ambient temperature

5: 1.) 80percent NaH / 1.) DMF, paraffin, r.t., 1 h, 2.) DMF, paraffin, 1 h

6: 71 percent / 1.0M DIBAH/C₆H₁₄ / toluene / 1 h / -78 °C

With sodium tetrahydroborate; n-butyllithium; aluminium trichloride; C₆H₁₄; sodium hydride; diisobutylaluminium hydride; trifluoroacetic acid; HSiPh₃; In methanol; dichloromethane; toluene;
DOI:10.1002/ardp.19943270602