{2-[(Anthracene-9-carbonyl)-amino]-acetylamino}-acetic acid 11-[(Z)-3-(2,2-diphenyl-ethylcarbamoyl)-acryloylamino]-undecyl ester

Base Information

• Chemical Name: {2-[(Anthracene-9-carbonyl)-amino]-acetylamino}-acetic acid 11-[(Z)-3-(2,2-diphenyl-ethylcarbamoyl)-acryloylamino]-undecyl ester
• CAS No.: 792917-47-6
• Molecular Formula: C₄₈H₅₄N₄O₆
• Molecular Weight: 782.98
• Mol file: 792917-47-6.mol

Synonyms:{2-[(Anthracene-9-carbonyl)-amino]-acetylamino}-acetic acid 11-[(Z)-3-(2,2-diphenyl-ethylcarbamoyl)-acryloylamino]-undecyl ester

Chemical Property of {2-[(Anthracene-9-carbonyl)-amino]-acetylamino}-acetic acid 11-[(Z)-3-(2,2-diphenyl-ethylcarbamoyl)-acryloylamino]-undecyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {2-[(Anthracene-9-carbonyl)-amino]-acetylamino}-acetic acid 11-[(Z)-3-(2,2-diphenyl-ethylcarbamoyl)-acryloylamino]-undecyl ester

There total 6 articles about {2-[(Anthracene-9-carbonyl)-amino]-acetylamino}-acetic acid 11-[(Z)-3-(2,2-diphenyl-ethylcarbamoyl)-acryloylamino]-undecyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

(Z)-3-(2,2-diphenylethylcarbamoyl)acrylic acid (573986-21-7) + {2-[(anthracene-9-carbonyl)-amino]-acetylamino}-acetic acid 11-amino-undecyl ester → {2-[(Anthracene-9-carbonyl)-amino]-acetylamino}-acetic acid 11-[(Z)-3-(2,2-diphenyl-ethylcarbamoyl)-acryloylamino]-undecyl ester (792917-47-6)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/ja0484193

Reference yield:

1-Bromo-11-hydroxyundecane (1611-56-9) → {2-[(Anthracene-9-carbonyl)-amino]-acetylamino}-acetic acid 11-[(Z)-3-(2,2-diphenyl-ethylcarbamoyl)-acryloylamino]-undecyl ester (792917-47-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 98 percent / dimethylformamide / 2 h / 80 °C

2: hydrazine hydrate / ethanol / 0.5 h / Heating

3: 100 percent / NaOH / methanol

4: 60 percent / 4-(dimethylamino)pyridine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CHCl₃ / 6 h / 20 °C

5: trifluoroacetic acid / CH₂Cl₂

6: 55 percent / 4-(dimethylaminp)pyridine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂; dimethylformamide / 20 °C

With dmap; sodium hydroxide; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1021/ja0484193

Reference yield:

11-aminoundecan-1-ol (27780-89-8) → {2-[(Anthracene-9-carbonyl)-amino]-acetylamino}-acetic acid 11-[(Z)-3-(2,2-diphenyl-ethylcarbamoyl)-acryloylamino]-undecyl ester (792917-47-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / NaOH / methanol

2: 60 percent / 4-(dimethylamino)pyridine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CHCl₃ / 6 h / 20 °C

3: trifluoroacetic acid / CH₂Cl₂

4: 55 percent / 4-(dimethylaminp)pyridine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂; dimethylformamide / 20 °C

With dmap; sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1021/ja0484193

upstream raw materials:

(Z)-3-(2,2-diphenylethylcarbamoyl)acrylic acid

11-aminoundecan-1-ol

1-Bromo-11-hydroxyundecane

(11-hydroxyundecyl)carbamic acid tert-butyl ester