N-(3-((2-((4-(morpholinomethyl)phenyl)amino)thieno[3,2-d] pyrimidin-4-yl)oxy)phenyl)acrylamide

Base Information

• Chemical Name: N-(3-((2-((4-(morpholinomethyl)phenyl)amino)thieno[3,2-d] pyrimidin-4-yl)oxy)phenyl)acrylamide
• CAS No.: 1353552-20-1
• Molecular Formula: C₂₆H₂₅N₅O₃S
• Molecular Weight: 487.582
• Mol file: 1353552-20-1.mol

Synonyms:N-(3-((2-((4-(morpholinomethyl)phenyl)amino)thieno[3,2-d] pyrimidin-4-yl)oxy)phenyl)acrylamide

Chemical Property of N-(3-((2-((4-(morpholinomethyl)phenyl)amino)thieno[3,2-d] pyrimidin-4-yl)oxy)phenyl)acrylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-((2-((4-(morpholinomethyl)phenyl)amino)thieno[3,2-d] pyrimidin-4-yl)oxy)phenyl)acrylamide

There total 5 articles about N-(3-((2-((4-(morpholinomethyl)phenyl)amino)thieno[3,2-d] pyrimidin-4-yl)oxy)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.8%

4-morpholinomethyl aniline (51013-67-3) + N-(3-((2-chlorothieno[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide → N-(3-((2-((4-(morpholinomethyl)phenyl)amino)thieno[3,2-d] pyrimidin-4-yl)oxy)phenyl)acrylamide (1353552-20-1)

Guidance literature:

With toluene-4-sulfonic acid; In butan-1-ol; at 70 ℃; for 6h;

DOI:10.1016/j.bmc.2019.115254

Reference yield:

4-(4-nitrobenzyl)morpholine (6425-46-3) → N-(3-((2-((4-(morpholinomethyl)phenyl)amino)thieno[3,2-d] pyrimidin-4-yl)oxy)phenyl)acrylamide (1353552-20-1)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium chloride; iron / water; methanol / 2 h / 70 °C

2: toluene-4-sulfonic acid / butan-1-ol / 6 h / 70 °C

With iron; ammonium chloride; toluene-4-sulfonic acid; In methanol; water; butan-1-ol;

DOI:10.1016/j.bmc.2019.115254

Reference yield:

1-bromomethyl-4-nitro-benzene (100-11-8) → N-(3-((2-((4-(morpholinomethyl)phenyl)amino)thieno[3,2-d] pyrimidin-4-yl)oxy)phenyl)acrylamide (1353552-20-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

2: ammonium chloride; iron / water; methanol / 2 h / 70 °C

3: toluene-4-sulfonic acid / butan-1-ol / 6 h / 70 °C

With iron; potassium carbonate; ammonium chloride; toluene-4-sulfonic acid; In methanol; water; N,N-dimethyl-formamide; butan-1-ol;

DOI:10.1016/j.bmc.2019.115254

upstream raw materials:

4-morpholinomethyl aniline

4-(4-nitrobenzyl)morpholine

1-bromomethyl-4-nitro-benzene

m-Hydroxyaniline