3-(trifluoromethyl)-5,6,7,8-tetrahydro-5-methyl-[1,2,4]triazolo[4,3-a]pyrazine

Base Information

• Chemical Name: 3-(trifluoromethyl)-5,6,7,8-tetrahydro-5-methyl-[1,2,4]triazolo[4,3-a]pyrazine
• CAS No.: 723286-87-1
• Molecular Formula: C7H9 F3 N4
• Molecular Weight: 206.17
• Hs Code.: 2933990090
• Mol file: 723286-87-1.mol

Synonyms:5-methyl-3-trifluoromethyl-5,6,7,8-tetrahydro-1,2,4-triazolo[3,4-a]pyrazine;5-methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine;

Chemical Property of 3-(trifluoromethyl)-5,6,7,8-tetrahydro-5-methyl-[1,2,4]triazolo[4,3-a]pyrazine

Chemical Property:

• Vapor Pressure: 0.00716mmHg at 25°C
• Boiling Point: 269.6oC at 760 mmHg
• Flash Point: 116.9oC
• PSA: 42.74000
• Density: 1.63g/cm3
• LogP: 1.28990
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

5-Methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(trifluoromethyl)-5,6,7,8-tetrahydro-5-methyl-[1,2,4]triazolo[4,3-a]pyrazine

There total 4 articles about 3-(trifluoromethyl)-5,6,7,8-tetrahydro-5-methyl-[1,2,4]triazolo[4,3-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-(trifluoromethyl)-5-methyl-[1,2,4]triazolo[4,3-a]pyrazine (723286-86-0) → 5-methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine (723286-87-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; at 20 ℃; for 18h;

DOI:10.1021/jm070330v

Reference yield:

C7H6F2N4 → 5-methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine (723286-87-1)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃;

Reference yield:

2-hydrazino-6-methylpyrazine (19848-57-8) → 5-methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine (723286-87-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.17 h / Cooling with ice

2: palladium on activated charcoal; hydrogen / methanol / 20 °C

With palladium on activated charcoal; hydrogen; In methanol;

upstream raw materials:

3-(trifluoromethyl)-5-methyl-[1,2,4]triazolo[4,3-a]pyrazine

2-hydrazino-6-methylpyrazine

2-chloro-6-methylpyrazine