tert-Butyl 4-(2-amino-3-fluorophenylamino)piperidine-1-carboxylate

Base Information

Chemical Name:tert-Butyl 4-(2-amino-3-fluorophenylamino)piperidine-1-carboxylate
CAS No.:1004304-12-4
Molecular Formula:C₁₆H₂₄FN₃O₂
Molecular Weight:309.384
Hs Code.:
DSSTox Substance ID:DTXSID601142566
Mol file:1004304-12-4.mol

Synonyms:1004304-12-4;tert-Butyl 4-(2-amino-3-fluorophenylamino)piperidine-1-carboxylate;tert-butyl 4-(2-amino-3-fluoroanilino)piperidine-1-carboxylate;SCHEMBL4302207;DTXSID601142566;KS-5520;tert-Butyl4-(2-amino-3-fluorophenylamino)piperidine-1-carboxylate;1,1-Dimethylethyl 4-[(2-amino-3-fluorophenyl)amino]-1-piperidinecarboxylate

Suppliers and Price of tert-Butyl 4-(2-amino-3-fluorophenylamino)piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
tert-Butyl4-(2-amino-3-fluorophenylamino)piperidine-1-carboxylate 95%
1g
$ 407.00

Total 2 raw suppliers

Chemical Property of tert-Butyl 4-(2-amino-3-fluorophenylamino)piperidine-1-carboxylate

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:309.18525518
Heavy Atom Count:22
Complexity:378

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl4-(2-amino-3-fluorophenylamino)piperidine-1-carboxylate 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(CC1)NC2=C(C(=CC=C2)F)N

Technology Process of tert-Butyl 4-(2-amino-3-fluorophenylamino)piperidine-1-carboxylate

There total 3 articles about tert-Butyl 4-(2-amino-3-fluorophenylamino)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.2%

: 1004304-11-3
tert-butyl 4-((3-fluoro-2-nitrophenyl)amino)piperidine-1-carboxylate

: 1004304-12-4
tert-butyl 4-((2-amino-3-fluorophenyl)amino)piperidine-1-carboxylate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 5h; under 2280.15 Torr;

Reference yield:

: 19064-24-5
2,6-difluoro-1-nitrobenzene

: 1004304-12-4
tert-butyl 4-((2-amino-3-fluorophenyl)amino)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 70 °C

2: hydrogen / 5%-palladium/activated carbon / ethanol / 5 h / 20 °C / 2280.15 Torr

With hydrogen; potassium carbonate; 5%-palladium/activated carbon; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 1004304-12-4
tert-butyl 4-((2-amino-3-fluorophenyl)amino)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 70 °C

2: hydrogen / 5%-palladium/activated carbon / ethanol / 5 h / 20 °C / 2280.15 Torr

With hydrogen; potassium carbonate; 5%-palladium/activated carbon; In ethanol; N,N-dimethyl-formamide;