(1R,3S,4R,5S)-4-Acetylamino-3-hydroxy-5-methoxymethoxy-3-((1R,2R)-1,2,3-tris-methoxymethoxy-propyl)-cyclohexanecarboxylic acid tert-butyl ester

Base Information

Chemical Name:(1R,3S,4R,5S)-4-Acetylamino-3-hydroxy-5-methoxymethoxy-3-((1R,2R)-1,2,3-tris-methoxymethoxy-propyl)-cyclohexanecarboxylic acid tert-butyl ester
CAS No.:212752-19-7
Molecular Formula:C₂₄H₄₅NO₁₂
Molecular Weight:539.621
Hs Code.:

(1R,3S,4R,5S)-4-Acetylamino-3-hydroxy-5-methoxymethoxy-3-((1R,2R)-1,2,3-tris-methoxymethoxy-propyl)-cyclohexanecarboxylic acid tert-butyl ester

Synonyms:(1R,3S,4R,5S)-4-Acetylamino-3-hydroxy-5-methoxymethoxy-3-((1R,2R)-1,2,3-tris-methoxymethoxy-propyl)-cyclohexanecarboxylic acid tert-butyl ester

Suppliers and Price of (1R,3S,4R,5S)-4-Acetylamino-3-hydroxy-5-methoxymethoxy-3-((1R,2R)-1,2,3-tris-methoxymethoxy-propyl)-cyclohexanecarboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,3S,4R,5S)-4-Acetylamino-3-hydroxy-5-methoxymethoxy-3-((1R,2R)-1,2,3-tris-methoxymethoxy-propyl)-cyclohexanecarboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,3S,4R,5S)-4-Acetylamino-3-hydroxy-5-methoxymethoxy-3-((1R,2R)-1,2,3-tris-methoxymethoxy-propyl)-cyclohexanecarboxylic acid tert-butyl ester

There total 11 articles about (1R,3S,4R,5S)-4-Acetylamino-3-hydroxy-5-methoxymethoxy-3-((1R,2R)-1,2,3-tris-methoxymethoxy-propyl)-cyclohexanecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72-87-7,1136-42-1,1136-44-3,6082-29-7,6730-06-9,7772-94-3,10036-64-3,14131-60-3,14131-64-7,14131-68-1,14215-68-0,62057-49-2,62057-50-5,62057-51-6,62057-52-7,62057-53-8,62057-54-9,62057-55-0,62057-56-1,62075-50-7,62137-54-6,134451-97-1,134522-12-6,148347-16-4
N-acetyl-β-D-mannosamine

: 212752-19-7
(1R,3S,4R,5S)-4-Acetylamino-3-hydroxy-5-methoxymethoxy-3-((1R,2R)-1,2,3-tris-methoxymethoxy-propyl)-cyclohexanecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 80 percent / BF₃*Et₂O / 95 °C

2: 70 percent / p-TsOH / acetonitrile / 0 °C

3: 88 percent / CF₃SO₃H / tetrahydrofuran; diethyl ether / 0 °C

4: HCO₂H, Et₃N / Pd(PPh₃)4 / dioxane / 65 - 95 °C

5: AcOH / Ambient temperature

6: 70 percent / In, TBAI, H₂O, HCl / acetonitrile / 40 °C

7: 91 percent / (i-Pr)2NEt, TBAI, 4-pyrrolidinylpyridine / 1,2-dichloro-ethane / 0 - 25 °C

8: 92 percent / DDQ, H₂O / CH₂Cl₂ / Ambient temperature

9: 98 percent / Dess-Martin periodinane / CH₂Cl₂ / Ambient temperature

10: SmI₂, tert-BuOH / tetrahydrofuran; hexamethylphosphoric acid triamide / Ambient temperature

With hydrogenchloride; indium; formic acid; samarium diiodide; trifluorormethanesulfonic acid; boron trifluoride diethyl etherate; water; tetra-(n-butyl)ammonium iodide; Dess-Martin periodane; 4-pyrrolidin-1-ylpyridine; toluene-4-sulfonic acid; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tert-butyl alcohol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1002/(SICI)1521-3773(19980703)37:12<1732::AID-ANIE1732>3.0.CO;2-I

Reference yield:

: N-[(4aR,7S,8R,8aS)-6-Allyloxy-8-hydroxy-2-(4-methoxy-benzyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-acetamide

: 212752-19-7
(1R,3S,4R,5S)-4-Acetylamino-3-hydroxy-5-methoxymethoxy-3-((1R,2R)-1,2,3-tris-methoxymethoxy-propyl)-cyclohexanecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 88 percent / CF₃SO₃H / tetrahydrofuran; diethyl ether / 0 °C

2: HCO₂H, Et₃N / Pd(PPh₃)4 / dioxane / 65 - 95 °C

3: AcOH / Ambient temperature

4: 70 percent / In, TBAI, H₂O, HCl / acetonitrile / 40 °C

5: 91 percent / (i-Pr)2NEt, TBAI, 4-pyrrolidinylpyridine / 1,2-dichloro-ethane / 0 - 25 °C

6: 92 percent / DDQ, H₂O / CH₂Cl₂ / Ambient temperature

7: 98 percent / Dess-Martin periodinane / CH₂Cl₂ / Ambient temperature

8: SmI₂, tert-BuOH / tetrahydrofuran; hexamethylphosphoric acid triamide / Ambient temperature

With hydrogenchloride; indium; formic acid; samarium diiodide; trifluorormethanesulfonic acid; water; tetra-(n-butyl)ammonium iodide; Dess-Martin periodane; 4-pyrrolidin-1-ylpyridine; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tert-butyl alcohol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1002/(SICI)1521-3773(19980703)37:12<1732::AID-ANIE1732>3.0.CO;2-I

Reference yield:

: N-[(4aR,7S,8R,8aS)-6-Allyloxy-2-(4-methoxy-benzyl)-8-(4-methoxy-benzyloxy)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-acetamide

: 212752-19-7
(1R,3S,4R,5S)-4-Acetylamino-3-hydroxy-5-methoxymethoxy-3-((1R,2R)-1,2,3-tris-methoxymethoxy-propyl)-cyclohexanecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: HCO₂H, Et₃N / Pd(PPh₃)4 / dioxane / 65 - 95 °C

2: AcOH / Ambient temperature

3: 70 percent / In, TBAI, H₂O, HCl / acetonitrile / 40 °C

4: 91 percent / (i-Pr)2NEt, TBAI, 4-pyrrolidinylpyridine / 1,2-dichloro-ethane / 0 - 25 °C

5: 92 percent / DDQ, H₂O / CH₂Cl₂ / Ambient temperature

6: 98 percent / Dess-Martin periodinane / CH₂Cl₂ / Ambient temperature

7: SmI₂, tert-BuOH / tetrahydrofuran; hexamethylphosphoric acid triamide / Ambient temperature

With hydrogenchloride; indium; formic acid; samarium diiodide; water; tetra-(n-butyl)ammonium iodide; Dess-Martin periodane; 4-pyrrolidin-1-ylpyridine; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tert-butyl alcohol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1002/(SICI)1521-3773(19980703)37:12<1732::AID-ANIE1732>3.0.CO;2-I