5-{3-[3-bromo-5-fluoro-2-(methyloxy)phenyl]-1,2,4-oxadiazol-5-yl}-3-chloro-2-[(1-methylethyl)oxy]pyridine

Base Information

Chemical Name:5-{3-[3-bromo-5-fluoro-2-(methyloxy)phenyl]-1,2,4-oxadiazol-5-yl}-3-chloro-2-[(1-methylethyl)oxy]pyridine
CAS No.:1260022-53-4
Molecular Formula:C₁₇H₁₄BrClFN₃O₃
Molecular Weight:442.672
Hs Code.:

Synonyms:5-{3-[3-bromo-5-fluoro-2-(methyloxy)phenyl]-1,2,4-oxadiazol-5-yl}-3-chloro-2-[(1-methylethyl)oxy]pyridine

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Chemical Property of 5-{3-[3-bromo-5-fluoro-2-(methyloxy)phenyl]-1,2,4-oxadiazol-5-yl}-3-chloro-2-[(1-methylethyl)oxy]pyridine

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Technology Process of 5-{3-[3-bromo-5-fluoro-2-(methyloxy)phenyl]-1,2,4-oxadiazol-5-yl}-3-chloro-2-[(1-methylethyl)oxy]pyridine

There total 1 articles about 5-{3-[3-bromo-5-fluoro-2-(methyloxy)phenyl]-1,2,4-oxadiazol-5-yl}-3-chloro-2-[(1-methylethyl)oxy]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 187401-45-2
5-chloro-6-isopropoxynicotinic acid

: 1260022-41-0
3-bromo-5-fluoro-N-hydroxy-2-(methyloxy)benzenecarboximidamide

: 1260022-53-4
5-{3-[3-bromo-5-fluoro-2-(methyloxy)phenyl]-1,2,4-oxadiazol-5-yl}-3-chloro-2-[(1-methylethyl)oxy]pyridine

Guidance literature:: 5-chloro-6-isopropoxynicotinic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; In tetrahydrofuran; at 20 ℃; for 1h;

3-bromo-5-fluoro-N-hydroxy-2-(methyloxy)benzenecarboximidamide; In tetrahydrofuran; at 20 ℃; for 2h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 120 ℃; for 2h; Sealed; Microwave irradiation;

Reference yield:

: 1260022-53-4
5-{3-[3-bromo-5-fluoro-2-(methyloxy)phenyl]-1,2,4-oxadiazol-5-yl}-3-chloro-2-[(1-methylethyl)oxy]pyridine

: 193065-68-8
(3-ethoxy-3-oxopropyl)zinc(II) bromide

: 1260022-57-8
ethyl 3-[3-(5-{5-chloro-6-[(1-methylethyl)oxy]-3-pyridinyl}-1,2,4-oxadiazol-3-yl)-5-fluoro-2-(methyloxy)phenyl]propanoate

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

Reference yield:

: 1260022-53-4
5-{3-[3-bromo-5-fluoro-2-(methyloxy)phenyl]-1,2,4-oxadiazol-5-yl}-3-chloro-2-[(1-methylethyl)oxy]pyridine

: 151073-69-7
(4-ethoxy-4-oxobutyl)zinc(II) bromide

: 1260022-55-6
ethyl 4-[3-(5-{5-chloro-6-[(1-methylethyl)oxy]-3-pyridinyl}-1,2,4-oxadiazol-3-yl)-5-fluoro-2-(methyloxy)phenyl]butanoate

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;