6-methyl-5-(3'-methylisoxazol-5'-yl)-4-phenyl-2-(pyrazin-2-yl)-pyrimidine

Base Information

Chemical Name:6-methyl-5-(3'-methylisoxazol-5'-yl)-4-phenyl-2-(pyrazin-2-yl)-pyrimidine
CAS No.:1332886-93-7
Molecular Formula:C₁₉H₁₅N₅O
Molecular Weight:329.361
Hs Code.:

Synonyms:6-methyl-5-(3'-methylisoxazol-5'-yl)-4-phenyl-2-(pyrazin-2-yl)-pyrimidine

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Chemical Property of 6-methyl-5-(3'-methylisoxazol-5'-yl)-4-phenyl-2-(pyrazin-2-yl)-pyrimidine

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Technology Process of 6-methyl-5-(3'-methylisoxazol-5'-yl)-4-phenyl-2-(pyrazin-2-yl)-pyrimidine

There total 4 articles about 6-methyl-5-(3'-methylisoxazol-5'-yl)-4-phenyl-2-(pyrazin-2-yl)-pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 869287-27-4
1-amino-4-(3'-methylisoxazol-5'-yl)-3-phenyl-1-(pyrazin-2-yl)-2-azabutadiene

: 78-39-7
Triethyl orthoacetate

: 1332886-93-7
6-methyl-5-(3'-methylisoxazol-5'-yl)-4-phenyl-2-(pyrazin-2-yl)-pyrimidine

Guidance literature:: With zinc dibromide; In toluene; at 110 ℃; for 36h; Inert atmosphere;
DOI:10.1002/chem.201100040

Reference yield: 86.0%

: 18871-66-4
N,N-dimethylacetamide dimethyl acetal

: 869287-27-4
1-amino-4-(3'-methylisoxazol-5'-yl)-3-phenyl-1-(pyrazin-2-yl)-2-azabutadiene

: 1332886-93-7
6-methyl-5-(3'-methylisoxazol-5'-yl)-4-phenyl-2-(pyrazin-2-yl)-pyrimidine

Guidance literature:: at 120 ℃; for 2h; Inert atmosphere; Neat (no solvent);
DOI:10.1002/chem.201100040

Reference yield:

: 75632-83-6
3-methyl-5-[(trimethylsilyl)methyl]isoxazole

: 1332886-93-7
6-methyl-5-(3'-methylisoxazol-5'-yl)-4-phenyl-2-(pyrazin-2-yl)-pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -70 °C / Inert atmosphere

1.2: 1 h / -70 °C / Inert atmosphere

1.3: 20 °C / Inert atmosphere

2.1: 2 h / 120 °C / Inert atmosphere; Neat (no solvent)

With n-butyllithium; In tetrahydrofuran; hexane;
DOI:10.1002/chem.201100040