3-(4-{[4-(4-{2-[5-(2-carboxy-vinyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-1-methyl-1H-imidazol-4-ylcarbamoyl}-benzoylamino)-1-methyl-1H-imidazole-2-carbonyl]-amino}-1-methyl-1H-pyrrol-2-yl)-acrylic acid

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Chemical Name:3-(4-{[4-(4-{2-[5-(2-carboxy-vinyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-1-methyl-1H-imidazol-4-ylcarbamoyl}-benzoylamino)-1-methyl-1H-imidazole-2-carbonyl]-amino}-1-methyl-1H-pyrrol-2-yl)-acrylic acid
CAS No.:373362-10-8
Molecular Formula:C₃₄H₃₂N₁₀O₈
Molecular Weight:708.69
Hs Code.:

3-(4-{[4-(4-{2-[5-(2-carboxy-vinyl)-1-methyl-1<i>H</i>-pyrrol-3-ylcarbamoyl]-1-methyl-1<i>H</i>-imidazol-4-ylcarbamoyl}-benzoylamino)-1-methyl-1<i>H</i>-imidazole-2-carbonyl]-amino}-1-methyl-1<i>H</i>-pyrrol-2-yl)-acrylic acid

Synonyms:3-(4-{[4-(4-{2-[5-(2-carboxy-vinyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-1-methyl-1H-imidazol-4-ylcarbamoyl}-benzoylamino)-1-methyl-1H-imidazole-2-carbonyl]-amino}-1-methyl-1H-pyrrol-2-yl)-acrylic acid

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Chemical Property of 3-(4-{[4-(4-{2-[5-(2-carboxy-vinyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-1-methyl-1H-imidazol-4-ylcarbamoyl}-benzoylamino)-1-methyl-1H-imidazole-2-carbonyl]-amino}-1-methyl-1H-pyrrol-2-yl)-acrylic acid

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Technology Process of 3-(4-{[4-(4-{2-[5-(2-carboxy-vinyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-1-methyl-1H-imidazol-4-ylcarbamoyl}-benzoylamino)-1-methyl-1H-imidazole-2-carbonyl]-amino}-1-methyl-1H-pyrrol-2-yl)-acrylic acid

There total 8 articles about 3-(4-{[4-(4-{2-[5-(2-carboxy-vinyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-1-methyl-1H-imidazol-4-ylcarbamoyl}-benzoylamino)-1-methyl-1H-imidazole-2-carbonyl]-amino}-1-methyl-1H-pyrrol-2-yl)-acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 373362-02-8
3-(1-methyl-4-nitro-1H-pyrrol-2-yl)-acrylic acid ethyl ester

: 373362-10-8
3-(4-{[4-(4-{2-[5-(2-carboxy-vinyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-1-methyl-1H-imidazol-4-ylcarbamoyl}-benzoylamino)-1-methyl-1H-imidazole-2-carbonyl]-amino}-1-methyl-1H-pyrrol-2-yl)-acrylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: NaBH₄; Pd/C / methanol; H₂O / 0.33 h / 20 °C

2: 400 mg / i-Pr₂NEt / CH₂Cl₂ / 1 h / 20 °C

3: NaBH₄; Pd/C / methanol; H₂O / 0.33 h / 20 °C

4: i-Pr₂NEt / CH₂Cl₂ / 20 °C

5: H₂O; DBU / 20 °C

With sodium tetrahydroborate; palladium on activated charcoal; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; water;
DOI:10.1021/ja028459b

Reference yield:

: 373362-29-9
3-(4-amino-1-methyl-1H-pyrrol-2-yl)-acrylic acid ethyl ester

: 373362-10-8
3-(4-{[4-(4-{2-[5-(2-carboxy-vinyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-1-methyl-1H-imidazol-4-ylcarbamoyl}-benzoylamino)-1-methyl-1H-imidazole-2-carbonyl]-amino}-1-methyl-1H-pyrrol-2-yl)-acrylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 400 mg / i-Pr₂NEt / CH₂Cl₂ / 1 h / 20 °C

2: NaBH₄; Pd/C / methanol; H₂O / 0.33 h / 20 °C

3: i-Pr₂NEt / CH₂Cl₂ / 20 °C

4: H₂O; DBU / 20 °C

With sodium tetrahydroborate; palladium on activated charcoal; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; water;
DOI:10.1021/ja028459b

Reference yield:

: 373362-03-9
3-{1-methyl-4-[(1-methyl-4-nitro-1H-imidazole-2-carbonyl)-amino]-1H-pyrrol-2-yl}-acrylic acid ethyl ester

: 373362-10-8
3-(4-{[4-(4-{2-[5-(2-carboxy-vinyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl]-1-methyl-1H-imidazol-4-ylcarbamoyl}-benzoylamino)-1-methyl-1H-imidazole-2-carbonyl]-amino}-1-methyl-1H-pyrrol-2-yl)-acrylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: NaBH₄; Pd/C / methanol; H₂O / 0.33 h / 20 °C

2: i-Pr₂NEt / CH₂Cl₂ / 20 °C

3: H₂O; DBU / 20 °C

With sodium tetrahydroborate; palladium on activated charcoal; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; water;
DOI:10.1021/ja028459b