methyl 2,3,4-tri-O-acetyl-6-O-(p-tolylsulfonyl)-α-D-galactopyranoside

Base Information

• Chemical Name: methyl 2,3,4-tri-O-acetyl-6-O-(p-tolylsulfonyl)-α-D-galactopyranoside
• CAS No.: 52109-81-6
• Molecular Formula: C₂₀H₂₆O₁₁S
• Molecular Weight: 474.486
• Mol file: 52109-81-6.mol

Synonyms:methyl 2,3,4-tri-O-acetyl-6-O-(p-tolylsulfonyl)-α-D-galactopyranoside

Chemical Property of methyl 2,3,4-tri-O-acetyl-6-O-(p-tolylsulfonyl)-α-D-galactopyranoside

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2,3,4-tri-O-acetyl-6-O-(p-tolylsulfonyl)-α-D-galactopyranoside

There total 5 articles about methyl 2,3,4-tri-O-acetyl-6-O-(p-tolylsulfonyl)-α-D-galactopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

acetic anhydride (108-24-7) + methyl 6-O-tosyl-α-D-galactopyranoside (34698-19-6) → methyl 2,3,4-tri-O-acetyl-6-O-(p-tolylsulfonyl)-α-D-galactopyranoside (52109-81-6)

Guidance literature:

With pyridine; at 20 ℃; for 20h;

DOI:10.1081/CAR-100108283

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → methyl 2,3,4-tri-O-acetyl-6-O-(p-tolylsulfonyl)-α-D-galactopyranoside (52109-81-6)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 26 h / 20 °C

2: pyridine / 4 h / 20 °C

With pyridine;

DOI:10.1016/S0008-6215(02)00210-0

Reference yield:

O6-(toluene-4-sulfonyl)-β-D-galactopyranose (6619-07-4) → methyl 2,3,4-tri-O-acetyl-6-O-(p-tolylsulfonyl)-α-D-galactopyranoside (52109-81-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen chloride; methanol

2: pyridine

With pyridine; hydrogenchloride; methanol;

upstream raw materials:

acetic anhydride

methyl 6-O-tosyl-α-D-galactopyranoside

p-toluenesulfonyl chloride

O⁶-(toluene-4-sulfonyl)-β-D-galactopyranose

Downstream raw materials:

Acetic acid (2R,3R,4S,5R,6S)-4,5-diacetoxy-6-acetylsulfanylmethyl-2-(bis-benzyloxy-phosphoryloxy)-tetrahydro-pyran-3-yl ester

Methyl 6-amino-6-deoxy-α-D-galactopyranoside