Technology Process of methyl 2,6-difluoro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl)benzoate
There total 9 articles about methyl 2,6-difluoro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl)benzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C9H5ClF2O3; 1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene;
With
aluminum (III) chloride;
In
dichloromethane;
at 20 ℃;
for 0.333333h;
Reflux;
With
hydrogenchloride; water;
In
dichloromethane;
DOI:10.1002/cmdc.201200319
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.67 h
1.2: 5 h / 20 °C
2.1: aminosulfonic acid; sodium chlorite / water; acetonitrile / 1 h / 20 °C
3.1: thionyl chloride / 1 h / 84 °C
4.1: triethylamine / toluene / 1.17 h / 20 °C
5.1: hydrogen; 10% Pd/C / ethyl acetate; ethanol / 48 h / 20 °C
6.1: thionyl chloride / 1 h / 85 °C
7.1: aluminum (III) chloride / dichloromethane / 0.33 h / 20 °C / Reflux
With
aluminum (III) chloride; sodium chlorite; thionyl chloride; 10% Pd/C; aminosulfonic acid; hydrogen; sodium hydride; triethylamine;
In
ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;
DOI:10.1002/cmdc.201200319
- Guidance literature:
-
Multi-step reaction with 6 steps
1: aminosulfonic acid; sodium chlorite / water; acetonitrile / 1 h / 20 °C
2: thionyl chloride / 1 h / 84 °C
3: triethylamine / toluene / 1.17 h / 20 °C
4: hydrogen; 10% Pd/C / ethyl acetate; ethanol / 48 h / 20 °C
5: thionyl chloride / 1 h / 85 °C
6: aluminum (III) chloride / dichloromethane / 0.33 h / 20 °C / Reflux
With
aluminum (III) chloride; sodium chlorite; thionyl chloride; 10% Pd/C; aminosulfonic acid; hydrogen; triethylamine;
In
ethanol; dichloromethane; water; ethyl acetate; toluene; acetonitrile;
DOI:10.1002/cmdc.201200319
