2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid {4-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-phenyl}-amide

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Chemical Name:2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid {4-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-phenyl}-amide
CAS No.:1229419-06-0
Molecular Formula:C₂₇H₂₆F₃N₅O₃
Molecular Weight:525.53
Hs Code.:

Synonyms:2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid {4-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-phenyl}-amide

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Chemical Property of 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid {4-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-phenyl}-amide

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Technology Process of 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid {4-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-phenyl}-amide

There total 4 articles about 2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid {4-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-phenyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1085839-61-7
1-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperidine-4-carboxylic acid

: 849833-56-3,35613-84-4,1202858-97-6
N-hydroxyisobutyramidine

: 1229419-06-0
2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid {4-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-phenyl}-amide

Guidance literature:: 1-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperidine-4-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃;

N-hydroxyisobutyramidine; With triethylamine; In tetrahydrofuran; at 20 ℃;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1126-09-6
4-carbethoxypiperidine

: 1229419-06-0
2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid {4-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-phenyl}-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetonitrile / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 2585.81 Torr

3.1: triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

4.1: methanol; sodium hydroxide / 20 °C

5.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C

5.2: 20 °C

5.3: 20 °C

With methanol; oxalyl dichloride; hydrogen; potassium carbonate; triethylamine; N,N-dimethyl-formamide; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; sodium hydroxide; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 216985-30-7
ethyl 1-(4-Nitrophenyl)-4-piperidine carboxylate

: 1229419-06-0
2-phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid {4-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-phenyl}-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 2585.81 Torr

2.1: triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

3.1: methanol; sodium hydroxide / 20 °C

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C

4.2: 20 °C

4.3: 20 °C

With methanol; oxalyl dichloride; hydrogen; triethylamine; N,N-dimethyl-formamide; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; sodium hydroxide; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;