4-PIPERIDINAMINE, 4-METHYL-1-(PHENYLMETHYL)-

Base Information

• Chemical Name: 4-PIPERIDINAMINE, 4-METHYL-1-(PHENYLMETHYL)-
• CAS No.: 163271-06-5
• Molecular Formula: C13H20 N2
• Molecular Weight: 204.315
• Hs Code.: 2933399090
• Mol file: 163271-06-5.mol

Synonyms:(1-Benzyl-4-methylpiperidin-4-yl)amine;1-Benzyl-4-methyl-4-piperidinamine; 4-Amino-1-benzyl-4-methylpiperidine

Chemical Property of 4-PIPERIDINAMINE, 4-METHYL-1-(PHENYLMETHYL)-

Chemical Property:

• Boiling Point: 286℃
• PKA: 9.92±0.20(Predicted)
• Flash Point: 119℃
• PSA: 29.26000
• Density: 1.012
• LogP: 2.63800

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Benzyl-4-methylpiperidin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-PIPERIDINAMINE, 4-METHYL-1-(PHENYLMETHYL)-

There total 4 articles about 4-PIPERIDINAMINE, 4-METHYL-1-(PHENYLMETHYL)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-benzyl-4-acetylamino-4-methylpiperidine (155928-37-3) → 4-amino-1-benzyl-4-methylpiperidine (163271-06-5)

Guidance literature:

1-benzyl-4-acetylamino-4-methylpiperidine; With hydrogenchloride; water; for 168h; Heating / reflux;

With ammonia; water;

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → 4-amino-1-benzyl-4-methylpiperidine (163271-06-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetrahydrofuran; diethyl ether / -15 - 20 °C

2.1: sulfuric acid / 145 h / 20 °C / Cooling with ice-salt bath

2.2: pH 9

3.1: hydrogenchloride; water / 168 h / Heating / reflux

With hydrogenchloride; sulfuric acid; water; In tetrahydrofuran; diethyl ether;

Reference yield:

1-benzyl-4-methyl-piperidin-4-ol (3970-66-9) → 4-amino-1-benzyl-4-methylpiperidine (163271-06-5)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile

2: hydrogenchloride

In hydrogenchloride; acetonitrile;

upstream raw materials:

1-benzyl-4-acetylamino-4-methylpiperidine

1-benzyl-4-methyl-piperidin-4-ol

1-phenylmethyl-4-piperidone

Downstream raw materials:

tert-butyl 1-benzyl-4-methylpiperidin-4-ylcarbamate

1-(1-benzyl-4-methylpiperidin-4-yl)-3-(1-methylethyl)-1H-indole

1-(1-benzyl-4-methylpiperidin-4-yl)-6-fluoro-3-methyl-1H-indole

tert-butyl 4-(1-benzyl-4-methylpiperidin-4-ylcarbamoyl)-3-methoxyphenylcarbamate

Refernces

• 1、 Muehlhausen, Ute,Ermert, Johannes,Coenen, Heinz H.. "Synthesis, labelling and first evaluation of [18F]R91150 as a serotonin 5-HT2A receptor antagonist for PET". experimental part. p. 13 - 22. Retrieved 2009/04/18.
• 2、 Nitta, Aiko,Fujii, Hideaki,Sakami, Satoshi,Nishimura, Yutaka,Ohyama, Tomofumi,Satoh, Mikiya,Nakaki, Junko,Satoh, Shiho,Inada, Chifumi,Kozono, Hideki,Kumagai, Hiroki,Shimamura, Masahiro,Fukazawa, Tominaga,Kawai, Hideki. "(3R)-3-Amino-4-(2,4,5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-yl}butanamide as a potent dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes". scheme or table. p. 5435 - 5438. Retrieved 2009/05/30.