4-Aminomethyl-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-Aminomethyl-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 620611-27-0
• Molecular Formula: C11H21FN2O2
• Molecular Weight: 232.298
• Hs Code.: 2933399090
• Mol file: 620611-27-0.mol

Synonyms:4-(Aminomethyl)-4-fluoropiperidine-1-carboxylicacid tert-butyl ester;

Chemical Property of 4-Aminomethyl-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

• Refractive Index: 1.483
• Boiling Point: 302.4 °C at 760 mmHg
• PKA: 10.13±0.29(Predicted)
• Flash Point: 136.7 °C
• PSA: 55.56000
• Density: 1.09 g/cm³
• LogP: 2.32250
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99.0% ^*data from raw suppliers

tert-Butyl4-(Aminomethyl)-4-fluoropiperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: tert-Butyl 4-(aminomethyl)-4-fluoropiperidine-1-carboxylate is a useful intermediate in the synthesis of 4-aminomethyl-4-fluoropiperidine derivatves used as T-type Ca2+ channel antagonist.

Technology Process of 4-Aminomethyl-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester

There total 8 articles about 4-Aminomethyl-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

tert-butyl 4-[(N,N-dibenzylamino)methyl]-4-fluoropiperidine-1-carboxylate → 4-aminomethyl-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester (620611-27-0)

Guidance literature:

With hydrogen; palladium(II) hydroxide; In methanol; for 8h;

Reference yield: 67.0%

tert-butyl 4-azidomethyl-4-fluoropiperidine-1-carboxylate (1228765-02-3) → 4-aminomethyl-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester (620611-27-0)

Guidance literature:

With 1% Pd/C; hydrogen; In methanol; at 20 ℃; for 16h; under 3450.35 Torr;

DOI:10.1039/c003380d

Reference yield: 15.0%

4-cyano-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester (918431-93-3) → 4-aminomethyl-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester (620611-27-0)

Guidance literature:

DOI:10.1039/c003380d

upstream raw materials:

4-cyano-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester

4-[(1,3-dioxoisoindolin-2-yl)methyl]-4-fluoropiperidinecarboxylic acid tert-butyl ester

tert-butyl 4-azidomethyl-4-fluoropiperidine-1-carboxylate

1-oxa-6-aza-spiro-[2.5]octane-6-caboxylic acid tert-butyl ester

Downstream raw materials:

tert-butyl 4-fluoro-4-((3-fluoro-5-(trifluoromethyl)benzamido)methyl)piperidine-1-carboxylate

tert-butyl 4-((3,5-dichlorobenzamido)methyl)-4-fluoropiperidine-1-carboxylate

Refernces

• 1、 -. "INDAZOLE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS". . . Retrieved 2015/07/07.
• 2、 -. "Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-like Proteins". Page/Page column 20. . Retrieved 2011/10/31.